Nodular Regenerative Hyperplasia – an under-recognized vascular disorder of liver

ConclusionThis study highlights the role of pathologist in the diagnosis of NRH and stresses upon the need for awareness of NRH as a cause of unexplained portal hypertension in patients with underlying systemic diseases. The altered perfusion state in NRH leads to phenotypic shift in centrizonal atrophic hepatocytes and sinusoidal endothelial cells (as depicted by IHC) which may be responsible for development of portal hypertension.
Source: Pathology Research and Practice - Category: Pathology Source Type: research