Don't cut salt completely: Animal study discovers that high-salt diets can inhibit tumor growth

(Natural News) Having too much salt in your diet is incredibly unhealthy. High-salt intake can exacerbate conditions like multiple sclerosis and inflammatory bowel diseases. However, when it comes to cancer, a team of researchers is now suggesting that increasing the amount of salt in your diet may have some beneficial effects, particularly when it comes to fighting...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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Abstract Chromatin 'readers' are central interpreters of the epigenome that facilitate cell-specific transcriptional programs and are therapeutic targets in cancer and inflammation. The Speckled Protein (SP) family of chromatin 'readers' in humans consists of SP100, SP110, SP140, and SP140L. SPs possess functional domains (SAND, PHD, bromodomain) that dock to DNA or post-translationally modified histones and a caspase activation and recruitment domain (CARD) domain to promote multimerization. Mutations within immune expressed SPs associate with numerous immunological diseases including Crohn's disease, multiple sc...
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Tags: Trends Immunol Source Type: research
HORSHAM, PA, April 24, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced the submission of two supplemental Biologics License Applications (sBLA) to the U.S. Food and Drug Administration (FDA) seeking approval of SIMPONI ARIA® (golimumab) for the treatment of polyarticular juvenile idiopathic arthritis (pJIA) and juvenile psoriatic arthritis (jPsA), in patients two years of age and older in combination with methotrexate. If approved for these indications, SIMPONI ARIA would be the first anti-tumor necrosis factor (TNF)-alpha biologic agent administered by intravenous infusion ava...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Authors: Teixeira FCOB, Götte M Abstract The cell surface heparan sulfate proteoglycan Syndecan-1 acts as an important co-receptor for receptor tyrosine kinases and chemokine receptors, and as an adhesion receptor for structural glycoproteins of the extracellular matrix. It serves as a substrate for heparanase, an endo-β-glucuronidase that degrades specific domains of heparan sulfate carbohydrate chains and thereby alters the functional status of the proteoglycan and of Syndecan-1-bound ligands. Syndecan-1 and heparanase show multiple levels of functional interactions, resulting in mutual regulation of th...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
  Cannabis, weed, marijuana, pot. It goes by several names, but we all know what it smells like. As weed becomes more mainstream, we on the Not Crazy podcast want to know: Is marijuana really an effective treatment for anxiety? Is it just a coping mechanism? Or a vice? In today’s podcast, Gabe and Jackie look at the research and weigh out the evidence. They also interview Eileen Davidson, a rheumatoid arthritis patient who regularly uses marijuana as a medicine to see what she has to say. What’s your take? Tune in for an open-minded discussion about weed. (Transcript Available Below) SUBSCRIBE &REV...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic General Medications Not Crazy Podcast Source Type: blogs
Hairy, scary, funny looking or pretty cool. The beasts in the Harry Potter universe are quite the diverse bunch with unique abilities and qualities. Just like new digital health tech targeted to fight autoimmune diseases or for the main part: their symptoms. Source: Warner Bros. Framestore The common ground for completely different illnesses like type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis is an immune system disfunction. Immune cells and mechanisms target the body’s own cells and structures, deconstructing it bit by bit and inducing inflammation. An estim...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Biotechnology Future of Medicine chatbot diabetes digital health sleep optimization chronic pain chronic illness skin coronavirus autoimmune disease Source Type: blogs
  Are people with mental illness more creative? Jackie believes there may be a link between the two, while Gabe thinks it’s just a bunch of hoopla. Get ready — they’ve both done their research and are ready to back their claims. Tune in to hear a lively (and friendly) debate on whether the science is valid, the difference between inspiration and creativity, as well as their own opinions and experiences on mental illness and creativity. What’s your take? Join us on this Not Crazy podcast to see whose side you’re on, or if you’re somewhere in the middle. (Transcript Available Belo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Creativity Disorders General Mental Health and Wellness Not Crazy Podcast Schizophrenia Source Type: blogs
Choi The integration of computational techniques into drug development has led to a substantial increase in the knowledge of structural, chemical, and biological data. These techniques are useful for handling the big data generated by empirical and clinical studies. Over the last few years, computer-aided drug discovery methods such as virtual screening, pharmacophore modeling, quantitative structure-activity relationship analysis, and molecular docking have been employed by pharmaceutical companies and academic researchers for the development of pharmacologically active drugs. Toll-like receptors (TLRs) play a vital ...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
(Natural News) Having too much salt in your diet is incredibly unhealthy. High-salt intake can exacerbate conditions like multiple sclerosis and inflammatory bowel diseases. However, when it comes to cancer, a team of researchers is now suggesting that increasing the amount of salt in your diet may have some beneficial effects, particularly when it comes to fighting...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates its biological roles through a hexameric complex composed of IL-6 itself, its receptor IL-6R, and glycoprotein 130 (IL-6/IL-6R/gp130). This complex, in turn, activates different signaling mechanisms (classical and trans-signaling) to execute various biochemical functions. The trans-signaling mechanism activates various pathological routes, like JAK/STAT3, Ras/MAPK, PI3K-PKB/Akt, and regulation of CD4+ T cells and VEGF levels, which...
Source: Bioorganic and Medicinal Chemistry - Category: Chemistry Authors: Tags: Bioorg Med Chem Source Type: research
  Sex addict. Nympho. You’ve likely heard these words used for a person with hypersexuality, but what exactly is this condition? Is hypersexuality really a symptom of a mental disorder or is it just a super high libido? Where does one draw the line between liking (or loving) sex and being hypersexual? Is it similar to a drug addiction? Or a binge eating disorder?  Join Gabe and Jackie as they tackle this often misunderstood topic and hear Gabe’s own personal experiences with hypersexuality as a debilitating symptom of his bipolar disorder. (Transcript Available Below) SUBSCRIBE &REVIEW About Th...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Disorders General Not Crazy Podcast Relationships Sexuality Source Type: blogs
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