Satisfaction and Adherence With Glatiramer Acetate 40 mg/mL TIW in RRMS After 12 Months, and the Effect of Switching From 20 mg/mL QD
Conclusions: Data from the extension phase of the CONFIDENCE study show that the benefits associated with GA40 treatment in terms of medication satisfaction, treatment convenience perception, symptomatic changes in fatigue impact and mental health status, and treatment adherence were maintained over a 12-month observation period. These results confirm the preferential utility of GA40 versus GA20 in clinical practice, with no additional safety concerns associated with switching from GA20 to GA40.
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Joanna Laurson-Doube, Nick Rijke, Kathleen Costello, Jennifer McDonell, Gavin Giovannoni, Brenda Banwell, Peer Baneke
Publication date: Available online 19 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Francesco Motolese, Mariagrazia Rossi, Emma Gangemi, Anna Bersano, Emma Scelzo, Vincenzo Di Lazzaro, Fioravante CaponeAbstractCerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a common cause of inherited stroke in young adults. CADASIL causes extensive white matter T2 hyperintensities at brain MRI, in particular involving anterior-temporal lobes and external capsules; usually, there is no spinal cord involvement. Since CADASIL clinical spectrum is heterogeneous ...
CONCLUSIONS The results indicate that, although persons with disabilities can exhibit a wide functional range, they remain at risk of PUs and should be evaluated for proper preventive measures, including support surfaces and wheelchair cushions.
Condition: Multiple Sclerosis Interventions: Other: Resistance training; Other: Testing sessions Sponsor: Universidad Católica San Antonio de Murcia Active, not recruiting
(Kessler Foundation) Researchers adapted the English language Kessler Foundation modified Story Memory Technique into Spanish. 'This is an example of how cultural adaptation can extend evidence-based interventions to non-English speaking populations,' said Dr. Krch. 'The positive outcomes of this pilot study of urban-based Mexicans have important implications. While further testing is needed, we anticipate that this adaptation of the modified Story Memory Technique will be applicable to the diverse Spanish-speaking population in the US, in addition to those with Mexican heritage.'
ConclusionAseptic meningitis may be an atypical phenotype of NMOSD flare that is easily confused with specific infection. Comprehensive evaluation to exclude an infective etiology and enable accurate diagnosis and timely immunotherapy are critical to prognosis.
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that is associated with demyelination and neuronal loss. Over recent years, the immunological and neuronal effects of tryptophan (Trp) metabolites have been largely investigated, leading to the hypothesis that these compounds and the related enzymes are possibly involved in the pathophysiology of MS. Specifically, the kynurenine pathway of Trp metabolism is responsible for the synthesis of intermediate products with potential immunological and neuronal effects. More recently, Trp metabolites, originating also from the host microbiome, have...
AbstractPurpose of ReviewTranscutaneous electrical nerve stimulation (TENS) is widely used as a non-pharmacological approach for pain relief in a variety of clinical conditions. This manuscript aimed to review the basic mechanisms and clinical applications regarding the use of TENS for alleviating the peripheral (PNP) and central neuropathic pain (CNP).Recent FindingsBasic studies on animal models showed that TENS could alleviate pain by modulating neurotransmitters and receptors in the stimulation site and its upper levels, including the spinal cord, brainstem, and brain. Besides, many clinical studies have investigated t...
In multiple sclerosis (MS) exercise improves upper limb functions, but it is unclear what training types are more effective.