Small World Index in Default Mode Network Predicts Progression from Mild Cognitive Impairment to Dementia.

Small World Index in Default Mode Network Predicts Progression from Mild Cognitive Impairment to Dementia. Int J Neural Syst. 2020 Jan 20;:2050004 Authors: Miraglia F, Vecchio F, Marra C, Quaranta D, Alù F, Peroni B, Granata G, Judica E, Cotelli M, Rossini PM Abstract Aim of this study was to explore the EEG functional connectivity in amnesic mild cognitive impairments (MCI) subjects with multidomain impairment in order to characterize the Default Mode Network (DMN) in converted MCI (cMCI), which converted to Alzheimer's disease (AD), compared to stable MCI (sMCI) subjects. A total of 59 MCI subjects were recruited and divided -after appropriate follow-up- into cMCI or sMCI. They were further divided in MCI with linguistic domain (LD) impairment and in MCI with executive domain (ED) impairment. Small World (SW) index was measured as index of balance between integration and segregation brain processes. SW, computed restricting to nodes of DMN regions for all frequency bands, evaluated how they differ between MCI subgroups assessed through clinical and neuropsychological four-years follow-up. In addition, SW evaluated how this pattern differs between MCI with LD and MCI with ED. Results showed that SW index significantly decreased in gamma band in cMCI compared to sMCI. In cMCI with LD impairment, the SW index significantly decreased in delta band, while in cMCI with ED impairment the SW index decreased in delta and gamma bands and in...
Source: International Journal of Neural Systems - Category: Neurology Authors: Tags: Int J Neural Syst Source Type: research