Therapy-induced senescence — an induced synthetic lethality in liver cancer?

Nature Reviews Gastroenterology & Hepatology, Published online: 21 January 2020; doi:10.1038/s41575-020-0262-3Cancer therapies, in addition to inducing cell death, can trigger cellular senescence of tumour cells, and factors secreted from senescent cells might negatively affect the tumour microenvironment. A new study by Wang et al. shows that eradication of therapy-induced senescent cells (senolysis) can improve the outcome of liver cancer therapy.

Source: Nature Reviews Gastroenterology and Hepatology - January 20, 2020 Category: Gastroenterology Authors: Katharina Wolter Lars Zender Source Type: research