Medication related osteonecrosis of the jaw (MRONJ) in patients taking high dose Simvastatin

Introduction: Osteonecrosis of the jaw (ONJ) is characterized by a chronic wound in the oral mucosa with exposed necrotic bone. This condition may occur following tooth extraction or other types of oral surgery, but may develop spontaneously adjacent to infected teeth or implant. The lesion may be symptomatic but is often asymptomatic. Both irradiation to the head and neck region (osteoradionecrosis) and bacterial infection, mainly Staphylococcus aureus (osteomyelitis), were long been known to cause this phenomenon (1).
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research