Gene Regulatory Effect of Pyruvate Kinase M2 is Involved in Renal Inflammation in Type 2 Diabetic Nephropathy

Conclusion The gene regulatory effect of PKM2 is involved in renal inflammation in type 2 diabetic nephropathy by promoting the phosphorylation of STAT3 and NF-kB and the expression of intercellular adhesion molecule 1. Thus, the down-regulation of phosphorylated PKM2 may have protective effects against diabetic nephropathy by inhibiting renal inflammation. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Experimental and Clinical Endocrinology and Diabetes - January 19, 2020 Category: Endocrinology Authors: Li, Le Tang, Lei Yang, Xiaoping Chen, Ruifang Zhang, Zhen Leng, Yiping Chen, Alex F. Tags: Article Source Type: research