Approaches to Microthrombotic Wounds: A Review of Pathogenesis and Clinical Features

GENERAL PURPOSE To discuss the pathogenesis and clinical features of wounds caused by microthrombi formation under the following categories of systemic diseases: cold-related and immune-complex deposition diseases, coagulopathies, abnormalities in red blood cell structure, emboli, and vasospasm. TARGET AUDIENCE This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES After participating in this educational activity, the participant should be better able to: 1. Recall the etiology, risk factors, and pathophysiology of the various types of microthrombotic wounds. 2. Describe the clinical manifestations and treatment of the various types of microthrombotic wounds. Typical wounds such as diabetic foot ulcers, venous leg ulcers, pressure ulcers, and arterial ulcers are responsible for more than 70% of chronic wounds. Atypical wounds have broad differential diagnoses and can sometimes develop as a combination of different conditions. Regardless of the etiology, impaired blood circulation is characteristic of all chronic and acute wounds. Chronic wounds associated with microthrombi formation are an important group of atypical wounds commonly linked to an underlying systemic disease. In this perspective article, the pathogenesis and clinical features of wounds caused by microthrombi formation are discussed under the following categories of syste...
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: CLINICAL MANAGEMENT EXTRA Source Type: research

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Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Abstract Chronic wounds are those that do not progress through a normal, orderly, and timely sequence of repair. They are common and are often incorrectly treated. The morbidity and associated costs of chronic wounds highlight the need to implement wound prevention and treatment guidelines. Common lower extremity wounds include arterial, diabetic, pressure, and venous ulcers. Physical examination alone can often guide the diagnosis. All patients with a nonhealing lower extremity ulcer should have a vascular assessment, including documentation of wound location, size, depth, drainage, and tissue type; palpation of ...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
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Source: Endocrine - Category: Endocrinology Source Type: research
AbstractDiabetic foot ulcers (DFU) are one of the most common diabetes complications and are associated with significant morbidity and mortality. Current DFU standard of care (SOC) involves four principles: (1) pressure relief, (2) debridement, (3) infection management, and (4) revascularization when indicated. Despite the current SOC, many DFU persist, warranting a new approach for the management of these complex wounds. This review aims to summarize the current SOC as well as the latest trends in adjunctive therapies that may become the new SOC in DFU management. These include negative pressure wound therapy and hyperbar...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
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Source: Medgadget - Category: Medical Devices Authors: Tags: Dermatology Materials Medicine Plastic Surgery Rehab Vascular Surgery Source Type: blogs
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Source: Medgadget - Category: Medical Devices Authors: Tags: Critical Care Exclusive Medicine Plastic Surgery Vascular Surgery Source Type: blogs
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