Activated Hgf-Met signaling cooperates with oncogenic Braf to drive primary cutaneous melanomas and angiotropic lung metastases in mice

Oncogenic mutations in the Braf-kinase gene represent the most frequent genomic driver in acquired melanocytic nevi and in cutaneous melanomas. It is currently thought that oncogene-induced senescence and cell cycle arrest limit the ability of oncogenic Braf to promote melanocyte proliferation in benign nevi. The molecular and cellular mechanisms that allow an oncogenic Braf mutation to fully transform melanocytes into invasively growing melanoma cells that are able to metastasize systemically are only partially understood.

Source: Journal of Investigative Dermatology - January 19, 2020 Category: Dermatology Authors: Andreas Dominik Braun, Miriam Mengoni, Susanne Bonifatius, Thomas T üting, Evelyn Gaffal Tags: Original Article Source Type: research