Specific IgA and CLA+ T-cell IL-17 response to Streptococcus pyogenes in psoriasis
Streptococcus pyogenes tonsillar infection is well-known to trigger and exacerbate psoriasis lesions in both guttate and plaque forms of the disease. Although mucosal and cutaneous tissues are closely involved in psoriasis pathology, the interaction between their specific immune responses has not been deeply explored. This work aims to address and characterize the presence of humoral responses against Streptococcus pyogenes in psoriasis patients and its putative association with cytokine responses detected in vitro in our psoriasis ex vivo model, based on the coculture of CLA+/- T cells with autologous epidermal cells.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Carmen De Jes ús-Gil, Lidia Sans-de San Nicolás, Ester Ruiz-Romeu, Marta Ferran, Laura Soria-Martinez, Anca Chiriac, Antonio Celada, Ramon M. Pujol, Luis F. Santamaria-Babí Tags: Original Article Source Type: research