Estimating the population health and economic impacts of introducing a pneumococcal conjugate vaccine in Malaysia- an economic evaluation

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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research

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Condition:   Pneumonia, Pneumococcal Intervention:   Biological: 23-Valent Pneumococcal Polysaccharide Vaccine Sponsor:   Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Publication date: Available online 17 February 2020Source: Journal of Molecular Graphics and ModellingAuthor(s): Julia Liang, Anita Mantelos, Zheng Quan Toh, Stephanie M. Tortorella, Katherine Ververis, Jitraporn Vongsvivut, Keith R. Bambery, Paul V. Licciardi, Andrew Hung, Tom C. KaragiannisAbstractStreptococcus pneumoniae infection can lead to pneumococcal disease, a major cause of mortality in children under the age of five years. In low- and middle-income country settings where pneumococcal disease burden is high, vaccine use is low and widespread antibiotic use has led to increased rates of multi-drug resistant pneumo...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
AbstractCommunity-acquired pneumonia (CAP) is the leading cause of death among infectious diseases and an important health problem, having considerable implications for healthcare systems worldwide. Despite important advances in prevention through vaccines, new rapid diagnostic tests and antibiotics, CAP management still has significant drawbacks. Mortality remains very high in severely ill patients presenting with respiratory failure or shock but is also high in the elderly. Even after a CAP episode, higher risk of death remains during a long period, a risk mainly driven by inflammation and patient-related co-morbidities....
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
A dosing schedule that includes three primary doses of pneumococcal conjugate vaccine (PCV) is associated with fewer breakthrough infections in the first year of life than are schedules with two primary doses, according to a new study of surveillance data.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pediatrics News Source Type: news
CONCLUSION: Through an interprofessional approach, we were able to achieve durable improvements in key rheumatology quality measures largely by enhancing workflow, engaging non-physician providers and managing practice variation. PMID: 32062597 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
ConclusionThe increase in the prevalence of CNSP using meningitis breakpoint was observed. For treating pneumococcal meningitis, empirical monotherapy with ceftriaxone might not be adequate. Imipenem and meropenem might not be a good choice for empirical treatment of adult IPDs. Antibiotic resistance of pneumococcus to ceftriaxone, cefepime, imipenem and meropenem were associated with 13-velent pneumococcal conjugate vaccine serotypes.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Extracellular vesicles are membranous structures shed by almost every living cell. Bacterial gram-negative outer membrane vesicles (OMVs) and gram-positive membrane vesicles (MVs) play important roles in adaptation to the surrounding environment, cellular components' exchange, transfer of antigens and virulence factors, and infection propagation. Streptococcus pneumoniae is considered one of the priority pathogens, with a global health impact due to the increase in infection burden and growing antibiotic resistance. We isolated MVs produced from the S. pneumoniae reference strain (R6) and purified them via size exclusion c...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Zaitoon H, Bamberger E, Yaniv L, Mendelson B, Srugo I, Chistyakov I Abstract BACKGROUND: The introduction of pneumococcal conjugate vaccine-13 (PCV-13) has reduced the burden of invasive pneumococcal disease. OBJECTIVES: To characterize true positive blood cultures of children who presented to our hospital following implementation of the PCV-13 vaccine. METHODS: A retrospective study was conducted on positive blood cultures of children presenting with fever from 2010-2017. Subjects were divided into two age groups: a younger group 3-36 months and an older group 3-18 years. Patients were classified ...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
CONCLUSION: The increase in the prevalence of CNSP using meningitis breakpoint was observed. For treating pneumococcal meningitis, empirical monotherapy with ceftriaxone might not be adequate. Imipenem and meropenem might not be a good choice for empirical treatment of adult IPDs. Antibiotic resistance of pneumococcus to ceftriaxone, cefepime, imipenem and meropenem were associated with 13-velent pneumococcal conjugate vaccine serotypes. PMID: 32063458 [PubMed - as supplied by publisher]
Source: Journal of Microbiology, Immunology, and Infection - Category: Microbiology Authors: Tags: J Microbiol Immunol Infect Source Type: research
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