Brain 18FDG-PET pattern in patients with alcohol-related cognitive impairment

AbstractPurposeBrain positron emission tomography using 18F-fluorodeoxyglucose (18FDG-PET) provides a metabolic assessment of brain function that is useful for differential diagnosis among several neurodegenerative diseases manifested by cognitive impairment (CI). The purpose of the study is to describe the pattern of 18FDG-PET abnormalities in patients with CI related to alcohol use disorder.MethodsPatients admitted to the addiction medicine department of a university hospital in Paris between January 2017 and October 2018 with a confirmed diagnosis of alcohol-related cognitive impairment (ARCI) or Wernicke encephalopathy (WE) were included. Brain 18FDG-PET uptake was measured after at least 1  month of monitored abstinence from alcohol. Standardized uptake values were obtained for 13 regions of interest (ROI) and normalized to the pons. Individual patients’ ROIZ-scores were calculated from healthy sex- and age-matched controls provided by Cortex ID software.ResultsTwenty-five patients were included in the analysis (20 males and 5 females; mean age 57.6  years (45–76 years old)). The group consisted of 19 ARCI and 6 WE cases. The mean hypometabolism was most severe in the prefrontal medial cortex (PFM) (− 2.80 (± 1.30)), the prefrontal lateral cortex (− 2.20 (± 1.35)), and the anterior cingulate cortex (− 2.24 (± 1.19)). Hy pometabolism (Z-score  
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research

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An efficient surface engineering strategy is proposed to significantly promote the electric conductivity, Zn ion diffusion rate, and cycling stability of MoO3 cathode for Zn ‐ion batteries. With the synergetic effect of Al2O3 coating and phosphating process, a fiber ‐shaped Zn‐ion battery based on modified MoO3 cathode presents favorable flexibility, admirable capacity, and superior rate performance. AbstractAqueous Zn ‐ion batteries (ZIBs) have garnered the researchers' spotlight owing to its high safety, cost effectiveness, and high theoretical capacity of Zn anode. However, the availability of cathode materials ...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
In this study, we collected raw water from different elements of a local full-scale plant to investigate the fouling characteristics along a two-stage-module NF process. The fouled membranes at different flux decline ratios were autopsied according to scanning electron microscope (SEM), atomic force microscope (AFM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectrometer (XPS), adenosine triphosphate (ATP), contact angle and zeta potential measurements to track the dynamic evolution of organic, inorganic and biological fouling. Statistical approaches, including principal component analysis (PCA), ...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
This study was conducted to evaluate the internet addiction and fear of missing out (FoMO) among nursing students.Design and MethodsThis descriptive study was conducted with 511 nursing students who consent to participate.ResultsIt was found that 3.8% (14 students) of the students participating in the research were “pathological internet users.” There was a positive correlation between internet addiction and FoMO (r = .332;P = .000).Practice ImplicationsThe finding that addiction increases with the increase in the use of social media show us that the excessive use of social media is ...
Source: Perspectives in Psychiatric Care - Category: Psychiatry Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusion: This study supports the psychometric properties of the Norwegian Self-Efficacy for Therapeutic Use of Self questionnaire in assessing self-efficacy in therapeutic encounters. Further research is needed to address the misfit items and the rating scale issue.Significance: Rasch analysis showed that the Norwegian Self-Efficacy for Therapeutic Use of Self questionnaire is promising to be used as a reliable and valid tool. PMID: 32065554 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
Conclusion: People who are overweight or obese are motivated to lose weight because of health issues and feeling more comfortable with their body. The opportunities for weight loss lie in creating habits, routines and structuring everyday life activities to facilitate a healthier lifestyle.Significance: The findings indicate that an occupational therapist should be part of weight-loss interventions. PMID: 32065553 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
Publication date: March 2020Source: Results in Physics, Volume 16Author(s): Sheng Zou, Hanbin Xiao, Fangping Ye, Zongchen Li, Wenzhi Tang, Feng Zhu, Chentong Chen, Chao ZhuAbstractThe inevitably formed residual stress in the Selective Laser Melting (SLM) process leads to distortion, crack and even delamination of the workpiece. Single laser is commonly applied during SLM processing. However, its productivity is much lower than multiple lasers. In addition, the research of residual stress with multi-laser condition currently is limited in the open documents. In this paper, a three-dimensional (3D) thermo-mechanical model, w...
Source: Results in Physics - Category: Physics Source Type: research
The objective of the study was to assess the diagnostic accuracy of ultrasonography in detecting nodular lesions in patients with subacute thyroiditis. We conducted a longitudinal study involving 710 patients with subacute thyroiditis who underwent ultrasonographic examinations in a single center between 2008 and 2018. These examinations were performed at initial diagnosis and during follow-up, with subsequent evaluation of nodules using fine needle aspiration cytology. Ultrasonographic examination used for the initial screening of thyroid nodules in patients with subacute thyroiditis showed a sensitivity of 72.4%, specifi...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Publication date: Available online 19 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Jeffrey W. Grimm, Frances SauterAbstractEnvironmental enrichment (EE) for rodents is generally defined as providing subjects with an environment enhanced with access to conspecifics, novel and tactile stimuli, and in many preparations, more space. EE exposure, in particular as an “intervention” in adult rodents, decreases food and drug seeking and taking. This review focuses on the reduction of sucrose seeking and taking in rats assessed in operant-based procedures. The operant-based model provides a mean...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Abstract OBJECTIVE: The survey aimed to estimate, in the presence of alcohol use disorder, the frequency of systematic prescription of thiamine, the factors associated with it, and those related to the administration (oral, intravenous, intramuscular) when Wernicke's encephalopathy is suspected. METHODS: A self-questionnaire available on Internet was sent by e-mail to doctors and nurses taking care patients with alcohol use disorder. RESULTS: In all, 565 professionals responded. The systematic prescription frequency of thiamine was 84.8 %, addiction care centers and medical-psychological center...
Source: Therapie - Category: Psychiatry & Psychology Authors: Tags: Therapie Source Type: research
Conclusion: Substitution of parenteral thiamine in individuals with suspected WE is a well-established treatment regimen. However, suggestions according to guidelines vary widely. Furthermore, hardly any evidence-based recommendations exist on a more general use of thiamine as a preventative intervention in individuals with AUD. Further research is of utmost importance to raise awareness for this potentially undervalued problem.Eur Addict Res 2019;25:103 –110
Source: European Addiction Research - Category: Addiction Source Type: research
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