Detecting Alzheimer's Disease Based on 4D fMRI: An Exploration Under Deep Learning Framework

Publication date: Available online 20 January 2020Source: NeurocomputingAuthor(s): Wei Li, Xuefeng Lin, Xi ChenAbstractApplying machine learning methods to various modality medical images and clinical data for early diagnosis of Alzheimer's disease (AD) and its prodromal stage has got lots of significant results. So far, the image data input to classifier mainly focus on 2D or 3D images. Although some functional imaging technologies, such as functional magnetic resonance imaging (fMRI), generate 4D data which contain both spatial and time-varying information of the brain, for the lack of suitable 4D image processing algorithm, these 4D data were always used by transforming them into functional connectivity or slicing them into 2D/3D pictures which causing apparent information loss. In this paper, we present a 4D deep learning model (C3d-LSTM) for AD discrimination, which is able to utilize the spatial and time-varying information simultaneously by dealing with 4D fMRI data directly. The proposed C3d-LSTM combines a series of 3D convolutional neural networks (CNNs) to extract spatial features from each volume of 3D static image in fMRI image sequence. Then the feature maps obtained were put into the long short-term memory (LSTM) network to capture the time-varying information contained in the data. Because of the design of structure, C3d-LSTM became an end-to-end data-driven model, which was more convenient for processing 4D fMRI data. The model proposed conducted on the AD Ne...
Source: Neurocomputing - Category: Neuroscience Source Type: research

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DISCUSSION: Our independently validated machine-learning model predicted cognitive decline in sporadic prodromal AD and may substantially reduce sample size needed in clinical trials in AD. PMID: 32043733 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
CONCLUSION: These results would be helpful in revealing the underlying pathological mechanism of the disease. PMID: 32053076 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
Emerging research indicates interruptions in the wiring organization of the brain network in Mild cognitive impairment (MCI) and Alzheimer's disease (AD). Due to the important role of rich-club organization in distinguishing abnormalities of AD patients and the close relationship between structural connectivity (SC) and functional connectivity (FC), our study examined whether changes in SC-FC coupling and the relationship with abnormal rich-club organizations during the development of diseases may contribute to the pathophysiology of AD. Structural diffusion-tensor imaging (DTI) and resting-state functional magnetic resona...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionCombination therapy with donepezil and kamikihito seems to be beneficial and worth considering for patients who are secondarily non ‐responsive to donepezil monotherapy.
Source: Traditional and Kampo Medicine - Category: Complementary Medicine Authors: Tags: CASE REPORT Source Type: research
This study demonstrates cognitive impairments in aged APOE4 knock-in mice after doxorubicin treatment and establishes this system as a novel and powerful model of CRCI. PMID: 32027870 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
Publication date: Available online 30 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Inés Del Cerro, Mirta F. Villarreal, Carolina Abulafia, Bárbara Duarte-Abritta, Stella M. Sánchez, Mariana N. Castro, Hernán Bocaccio, Isidre Ferrer, José Manuel Menchón, Gustavo Sevlever, Charles B. Nemeroff, Carles Soriano-Mas, Salvador M. GuinjoanAbstractPrevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays a neur...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive and irreversible cognitive decline. Currently, it affects 36 million people and due to population ageing it is estimated that in 2030 disease incidence will reach 60 million individuals. The precise diagnosis of AD is still a complex task, being mainly performed by cerebrospinal fluid (CSF) analysis or neuroimaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI). Despite being effective these techniques are expensive, time-consuming and not accessible for most part of the popu...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Molecules, Vol. 25, Pages 503: White Matter and Neuroprotection in Alzheimer’s Dementia Molecules doi: 10.3390/molecules25030503 Authors: Lorenzini Fernandez Baldassarro Bighinati Giuliani Calzà Giardino Myelin is the main component of the white matter of the central nervous system (CNS), allowing the proper electrical function of the neurons by ensheathing and insulating the axons. The extensive use of magnetic resonance imaging has highlighted the white matter alterations in Alzheimer’s dementia (AD) and other neurodegenerative diseases, alterations which are early, exten...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Authors: Baranowska-Wójcik E, Szwajgier D Abstract Introduction: Alzheimer's Disease (AD) is a progressive neurodegenerative pathology characterised by the presence of neuritic plaques and neurofibrillary tangles. The most important markers in AD pathology include excessive accumulation of amyloid beta (Aβ42) and phosphorylated tau (P-tau) proteins. One of the possible therapeutic strategies entails the elimination of such deposits by inhibiting Aβ aggregation. For years, one of the major problems in the treatment of AD has been the limited ability to deliver drugs to the brain for reasons related to ...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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