The Limits of the Linear Quadratic (LQ) Model for Late Cardiotoxicity Prediction: Example of Hypofractionated Rotational Intensity Modulated Radiation Therapy (IMRT) for Breast Cancer

Adjuvant radiation therapy decreases breast cancer mortality.1 Recent rotational techniques, such as volumetric modulated arc therapy (VMAT) and helical tomotherapy, additionally spare the heart.2,3 Hypofractionated breast rotational intensity modulated radiation therapy (IMRT) was well tolerated in prospective trials,4-6 but follow-up is insufficient and late cardiotoxicity remains unclear. With this in mind, we compared corrected mean doses to cardiac substructure between hypo- and normofractionated breast rotational IMRT.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Brief Report Source Type: research