Preclinical Evidence of Probiotics in Colorectal Carcinogenesis: A Systematic Review
ConclusionsThe different probiotics ’ strains showed anti-carcinogenic effect, reduced the development of lesions and intestinal tumors, antioxidant and immunomodulatory activity, and reduced fecal bacterial enzymes.
Publication date: Available online 17 February 2020Source: Pathology - Research and PracticeAuthor(s): Hyun Ji Son, Eun Ji Choi, Nam Jin Yoo, Sug Hyung Lee
Conditions: Cancer of Colon; Metastasis to Liver Intervention: Procedure: Scheduled and planned surgery Sponsor: Centre Leon Berard Not yet recruiting
Publication date: Available online 17 February 2020Source: International Journal of PharmaceuticsAuthor(s): Amin Afkhami-Poostchi, Mansour Mashreghi, Mehrdad Iranshahi, Maryam M. MatinAbstractBacteria-directed enzyme prodrug therapy (BDEPT), is an emerging alternative directed and tumor-specific approach. The basis of this method is the conversion of a non-toxic prodrug by a bacterial enzyme to a toxic drug within the tumor-microenvironment (TME). In the present study, the therapeutic efficacy of BDEPT was investigated based on the ability of Escherichia coli DH5α-lux/βG in activation of glycyrrhizic acid (GL), ...
The increase in colorectal cancer among younger adults has led to debate about lowering the age at which to begin screening.Medscape Medical News
The combination of chemotherapy and the epidermal-growth-factor receptor (EGFR) antibody cetuximab shortens survival compared with chemotherapy alone in certain patients with colorectal cancer, according to an open-label randomized trial.Reuters Health Information
(American Gastroenterological Association) These evidence-based recommendations support closer follow-up after colonoscopy screenings for some groups, less intense follow-up for others, and provide guidance for removing colorectal polyps.
Conclusions: Diabetes increased the risk of all-cause mortality among breast, prostate, and colorectal cancer survivors, not for pre- or post-diagnosis diabetes. Greater attention on diabetes management is warranted in cancer survivors with diabetes.
British Journal of Cancer, Published online: 18 February 2020; doi:10.1038/s41416-020-0754-5Benefits of switching from guaiac-based faecal occult blood to faecal immunochemical testing: experience from the Wallonia–Brussels colorectal cancer screening programme
British Journal of Cancer, Published online: 18 February 2020; doi:10.1038/s41416-020-0758-1miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells