Diabetes may increase risk of psychiatric disorders in adolescents

Adolescents and young adults with type 1 diabetes may have a greater likelihood of developing psychiatric disorders, according to a study published inDiabetes Care.Endocrinology Advisor
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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ConclusionActivation of autophagy can suppress the NLRP3 inflammasome formation, which in turn attenuates myocardial ischemia reperfusion injury in diabetic rats.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractThe pancreatic islet is a dense cellular network comprised of several cell types with endocrine function vital in the control of glucose homeostasis, metabolism, and feeding behavior. Within the islet, endocrine hormones also form an intricate paracrine network with supportive cells (endothelial, neuronal, immune) and secondary signaling molecules regulating cellular function and survival. Modulation of these signals has potential consequences for diabetes development, progression, and therapeutic intervention. Beta cell loss, reduced endogenous insulin secretion, and dysregulated glucagon secretion are hallmark fe...
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research
Authors: Barkai L, Kiss Z, Rokszin G, Abonyi-Tóth Z, Jermendy G, Wittmann I, Kempler P Abstract Introduction: The aim of the present study was to assess changes in the incidence and prevalence of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in children and adolescents in Hungary during the period 2001 to 2016 in order to provide nationwide population-based epidemiology data on diabetes in youths aged 0-18 years. Material and methods: This was a retrospective cohort study of Hungarian children and adolescents aged 18 years or younger. Pharmacologically treated diabetes cases were obtained through a p...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
This article examines the current state of the art, in particular summarizes data on the role of polymorphisms in Toll-like receptor genes in a number of autoimmune endocrine diseases, including type 1 diabetes mellitus, Graves' disease and Hashimoto's autoimmune thyroiditis. The search for relevant scientific data was carried out by entering search queries based on keywords: TLR, SNP, autoimmunity, Graves' disease, Type 1 diabetes mellitus, Hashimoto's autoimmune thyroiditis. The search was conducted through PubMed, MEDLINE, Elsevier journals, Science Direct and Russian Index of Scientific Citation, as well as other highl...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
AbstractIntroductionWe evaluated the effectiveness of long-term continuous subcutaneous insulin infusion (CSII) compared with multiple daily insulin (MDI) injections for glycaemic control and variability, hypoglycaemic episodes and maternal/neonatal outcomes in pregnant women with pre-existing type 1 diabetes (pT1D).MethodsOur observational cohort study included 128 consecutive pregnant women with pT1D, who were treated from 1 January 2010 to 31 December 2017. Of 128 participants, 48 were on CSII and 80 were on MDI. Glycaemic control was determined by glycated haemoglobin (HbA1c) (captured in preconception and each trimest...
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
This study aimed to evaluate the levels of interleukin-18 and tumor necrosis factor-alpha in gingival crevicular fluid of diabetic children with gingivitis.MethodologyEighty-eight children (44 with type 1 diabetes mellitus and 44 systemically healthy) were recruited for the study. The children were divided into four subgroups based on their periodontal and systemic condition: (1) systemically and periodontally healthy children (H), (2) systemically healthy children with gingivitis (G), (3) periodontally healthy children with T1DM (T1DM + H), and (4) children with T1DM and gingivitis (T1DM + G). The plaque index, gingival i...
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
Condition:   Diabetes Mellitus, Type 1 Interventions:   Device: Medtronic Minimed 670G 3.0 HCL;   Device: Medtronic Minimed 670G 4.0 AHCL Sponsors:   Rabin Medical Center;   GIF;   Medtronic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Type 1 Diabetes Intervention:   Device: DreaMed Advisor Pro Sponsor:   Rabin Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Diabetes Mellitus, Type 1 Intervention:   Biological: teplizumab Sponsor:   Provention Bio, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study compared extracted structured EHR data with chart review from endocrinologists’ health-care records at a large, academic ambulatory hospital in Toronto, Ontario.MethodsConsecutive chart review for the first 10 patients with either type 1 or type 2 diabetes seen between January 1, 2015 and March 1, 2016 was sampled for each of the 10 endocrinologists within the diabetes program, and electronic data extraction was also completed for a core set of structured diabetes care elements. Fisher exact test was used to determine differences in data availability between extracted EHR data and chart review.ResultsOut o...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
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