IL-24 inhibits endometrial cancer cell proliferation by promoting apoptosis through the mitochondrial intrinsic signaling pathway
ConclusionsOur study demonstrates the antitumor effect of IL-24 on endometrial cancer and shows that IL-24 may be a promising therapeutic gene for endometrial cancer gene therapy.Graphical abstract
Publication date: Available online 19 February 2020Source: SteroidsAuthor(s): Serene A. Badran, Atia-tul-Wahab, Sharmeen Fayyaz, Bushra Taj, M. Iqbal ChoudharyAbstractAimsDrug repurposing or repositioning i.e; identifying new indications for existing drugs have recently accelerate the process of drug development and discovery. Megestrol acetate (1) is a well-known progestin. It is commonly used as an appetite stimulant, and also in the treatment of breast, and endometrial cancer. The aim of this study is to investigate the effect of megestrol acetate (1) in osteoblast differentiation, and to determine the possible mechanis...
CONCLUSIONS: Our data support the adoption of the surgical management of the morbidly obese patient. Although short term complication rates are higher with increasing obesity (II-III class), a majority of procedures can still be completed with minimally invasive approach. PMID: 32064825 [PubMed - in process]
A study published in theJournal of Medical Genetics identifies risk factors for endometrial cancer that could help develop targeted screening and prevention strategies.Science Codex
Endometrial cancer (EC) is one kind of women cancers. Bioinformatic technology could screen out relative genes which made targeted therapy becoming conventionalized.
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Publication date: Available online 17 February 2020Source: Life SciencesAuthor(s): Luiz Antonio Lupi, Maira Smaniotto Cucielo, Henrique Spaulonci Silveira, Letícia Barbosa Gaiotte, Roberta Carvalho Cesário, Fábio Rodrigues Ferreira Seiva, Luiz Gustavo de Almeida ChuffaAbstractToll-like receptors (TLRs) are critical sensors related to inflammation and tumorigenesis. Among all subtypes, the TLR4 is a highly described transmembrane protein involved in the inflammatory process. The TLR4/myeloid differentiation factor 88 (MyD88) signaling pathway has been implicated in oncogenic events in several tissues an...
(University of Manchester) An analysis of 149 scientific studies has identified 24 genetic variants which predispose women to endometrial cancer.
(BMJ) Twenty four common variations in genes coding for cell growth and death, the processing of oestrogen, and gene control factors may be linked to a heightened risk of developing womb (endometrial) cancer, indicates the most comprehensive review of the published evidence so far in the Journal of Medical Genetics.
Tumor microenvironment (TME) including the immune checkpoint system impacts prognosis in some types of malignancy. The aim of our study was to investigate the precise prognostic significance of the TME profile...