Cartilage tissue formation from human adipose ‑derived stem cells via herbal component (Avocado/soybean unsaponifiables) in scaffold‑free culture system

Conclusion: It can be concluded that A/S similar to TGF ‑β1 is able to facilitate the chondrogenicdifferentiation of hADSCs and do not have adverse effects of TGF ‑β1. Thus, TGF‑β1 can be replacedby A/S in the field of tissue engineering.
Source: Dental Research Journal - Category: Dentistry Source Type: research

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Publication date: Available online 19 February 2020Source: Polymer Degradation and StabilityAuthor(s): Marziyeh Ranjbar Mohammadi, Saeid Kargozar, S.H. Bahrami, Shahram RabbaniAbstractIn this research, the scaffolds from gum tragacanth (GT), poly (Ɛ-caprolactone) (PCL) and poly (vinyl alcohol) (PVA), were fabricated by electrospinning method for use in the healing of diabetic ulcers. At first, three different compositions from PCL-GT-PVA with blend ratios of (2:1:0.5), (2:1:0.8) and (2:1:1.5) were fabricated and the formulation 2:1:0.8 was selected as proper one. Then, the effect of changing GT concentration on the morpho...
Source: Polymer Degradation and Stability - Category: Chemistry Source Type: research
Cancer stem cells (CSC) are a distinct subpopulation within a tumor. They are able to self-renew and differentiate and possess a high capability to repair DNA damage, exhibit low levels of reactive oxygen species (ROS), and proliferate slowly. These features render CSC resistant to various therapies, including radiation therapy (RT). Eradication of all CSC is a requirement for an effective antineoplastic treatment and is therefore of utmost importance for the patient. This makes CSC the prime targets for any therapeutic approach. Albeit clinical data is still scarce, experimental data and first clinical trials give hope th...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Studies of the various approaches to raising NAD+ levels in aged mitochondria are a good illustration of the importance of the loss of mitochondrial function in degenerative aging. Researchers have studied this effect in numerous tissues and organs, with most such work examining muscle or the brain, both energy-hungry tissues and thus more dependent on their mitochondria for normal function. Today's open access paper is a study of mitochondrial function in a tissue that is less well studied in this context. The authors reporting that supplementation with nicotinamide mononucleotide (NMN) can restore lost fertility in old m...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Publication date: Available online 18 February 2020Source: Stem Cell ResearchAuthor(s): Alan T.L. Lam, Shaul Reuveny, Steve Kah-Weng OhAbstractArticular cartilage defects are one of the major challenges in orthopedic and trauma surgery. However, the poor ability of cartilage to self-repair has motivated efforts to engineer replacement tissues, and human mesenchymal stem cells (MSC), which have an extensive proliferation potential and can undergo chondrogenesis, have emerged as a promising cell source. In this review, we attempt to provide a brief overview of MSC isolation, characterization, current manufacturing platforms ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
ConclusionDe-hUC-MSCs reprogramming of endogenous hSDF-1α expression may mediate the hSDF-1α/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats.
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
Contributors : Shiri Gur-Cohen ; Hanseul Yang ; Elaine FuchsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissues rely on stem cells (SCs) for homeostasis and wound-repair. SCs reside in specialized microenvironments (niches) whose complexities and roles in orchestrating tissue growth are still unfolding. Here, we identify lymphatic capillaries as critical SC niche components. In skin, lymphatics form intimate networks around the SCs of each hair follicle (HF) during their non-regenerative phase, and remodel upon regeneration. Seeking understanding, we unravel a secretome switch wit...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Shiri Gur-Cohen ; Hanseul Yang ; Elaine FuchsSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTissues rely on stem cells (SCs) for homeostasis and wound-repair. SCs reside in specialized microenvironments (niches) whose complexities and roles in orchestrating tissue growth are still unfolding. Here, we identify lymphatic capillaries as critical SC niche components. In skin, lymphatics form intimate networks around the SCs of each hair follicle (HF) during their non-regenerative phase, and remodel upon regeneration. Seeking understanding, we unravel a secret...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Shiri Gur-Cohen ; Hanseul Yang ; Elaine FuchsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissues rely on stem cells (SCs) for homeostasis and wound-repair. SCs reside in specialized microenvironments (niches) whose complexities and roles in orchestrating tissue growth are still unfolding. Here, we identify lymphatic capillaries as critical SC niche components. In skin, lymphatics form intimate networks around the SCs of each hair follicle (HF) during their non-regenerative phase, and remodel upon regeneration. Seeking understanding, we unravel a secretome switch wit...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Shiri Gur-Cohen ; Hanseul Yang ; Elaine FuchsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissues rely on stem cells (SCs) for homeostasis and wound-repair. SCs reside in specialized microenvironments (niches) whose complexities and roles in orchestrating tissue growth are still unfolding. Here, we identify lymphatic capillaries as critical SC niche components. In skin, lymphatics form intimate networks around the SCs of each hair follicle (HF) during their non-regenerative phase, and remodel upon regeneration. Seeking understanding, we unravel a secretome switch wit...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
AbstractCardiovascular diseases (CVDs) pose a serious threat to human health, which are characterized by high disability and mortality rate globally such as myocardial infarction (MI), atherosclerosis, and heart failure. Although stem cells transplantation and growth factors therapy are promising, their low survival rate and loss at the site of injury are major obstacles to this therapy. Recently, the development of hydrogel scaffold materials provides a new way to solve this problem, which have shown the potential to treat CVD. Among these scaffold materials, environmentally responsive hydrogels have great prospects in re...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
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