Comparison of Gut Microbiome in Human Colorectal Cancer in Paired Tumor and Adjacent Normal Tissues

Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

Related Links:

Publication date: Available online 18 February 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Anastasiia S. Garanina, Victor A. Naumenko, Aleksey A. Nikitin, Eirini Myrovali, Anna Y. Petukhova, Svetlana V. Klimyuk, Yulia A. Nalench, Artem R. Ilyasov, Stepan S. Vodopyanov, Alexander S. Erofeev, Peter V. Gorelkin, Makis Angelakeris, Alexander G. Savchenko, Ulf Wiedwald, Alexander G. Majouga Dr, Maxim A. AbakumovAbstractMagnetic hyperthermia (MHT) is a promising approach for cancer therapy. However, a systematic MHT characterization as function of temperature on the therapeutic efficiency is barely a...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: 1 April 2020Source: Journal of Molecular Liquids, Volume 303Author(s): Beata Brozek-Pluska, Adam Dziki, Halina AbramczykAbstractColon cancer is one of the most commonly detected pathology and is the third worldwide cause of death in the US and Europe and ranks second with regard to the incidence of malignant tumors in population. Raman spectroscopy and imaging can be used for colon cancer detection and bioanalytical characterization of noncancerous and pathologically changed tissues. These studies included Raman spectroscopy measurement of not fixed and not stained tissues samples. Presented study include...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Authors: Meunier L, Larrey D Abstract Some drugs may induce hepatotoxic lesions, such as steatosis or steatohepatitis found in Non-Alcoholic Fatty Liver Disease (NAFLD). Among these drugs there are some anti-tumoral molecules, such as methotrexate, 5-fluorouracil, irinotecan, tamoxifen and l-asparaginase. The hepatotoxic phenotype developed from treatment with such drugs is known as "CASH" for "Chemotherapy-induced Acute Steatohepatitis". The mechanism of toxicity is essentially based on mitochondrial toxicity. These lesions are chronic and often reversible when the treatment is stopped. Contrib...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Colorectal cancer (CRC) typically occurs when precancerous polyps in the colon or in the rectum transform into cancer. Signs of cancer may include rectal bleeding, blood in the stool, or a change in bowel movements. With routine screening, CRC can be prevented or detected early.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Tags: AGA Patient Education Section Source Type: research
(JAMA Network) More than 925,000 adults in the National Cancer Database with a new diagnosis of invasive breast, colon or lung cancer were included in this observational study that examined how Medicaid expansion under the Patient Protection and Affordable Care Act (ACA) was associated with insurance status, cancer stage at diagnosis and timely treatment.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
In this study, we searched for candidate microRNAs (miRNAs) by in silico analyses, which inhibit a stem cell-related gene Kr üppel-like factor 5 (KLF5). After in vitro screening we focused on miR-4711-5p which proved to inhibit cancer stemness and G1-S cell cycle progression. We found by luciferase binding assays that miR-4711-5p directly bound to KLF5, TFDP1 (a heterodimeric partner with E2F family), and MDM2 (one respo nsible gene for degradation of wild type p53). This miRNA suppressed cell proliferation, migration, and invasion ability in DLD-1 and HCT116 cells as well as the cancer stemness including low reactive...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Stephen N Housley ; Paul Nardelli ; Dario Carrasco ; Lilya V Matyunina ; Mengnan Zhang ; John F McDonald ; Tim C CopeSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusNeurological disorders induced by chemotherapy, including pain and other debilitating sensory conditions correlate with alterations in diverse systemic, cellular, and molecular processes. Chemotherapeutic agents variously induce inflammatory responses, metabolic disorders and associated gene expression changes, all of which have the capacity to impact sensory function . Early evidence of independent effects by cancer alone ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
Authors: Wei L, Chen J, Wen J, Wu D, Ma X, Chen Z, Huang J Abstract BACKGROUND The aim of this study was to perform an accurate exploration on the efficacy of oxaliplatin/5-fluorouracil/capecitabine-cetuximab combination therapy and its effects on K-Ras mutations in advanced colorectal cancer. MATERIAL AND METHODS Among 96 patients who suffered metastatic colorectal cancer without mutated K-Ras, 41 patients who were receiving treatment with oxaliplatin/5-fluorouracil/capecitabine and administered cetuximab as the initial treatment comprised the observation group; the remaining 55 patients receiving cetuximab as an ...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionsGroup pre-test genetic counselling combined with immediate “mini” individual session is strongly supported by patients and reduces wait times. Additional formal investigation of this approach in larger numbers of patients is warranted.
Source: Hereditary Cancer in Clinical Practice - Category: Cancer & Oncology Source Type: research
Volume 48, Issue 1, December 2020, Page 664-671 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - Category: Biotechnology Authors: Source Type: research
More News: Cancer | Cancer & Oncology | Colorectal Cancer