Viruses, Vol. 12, Pages 124: Identification of A Novel Papillomavirus Associated with Squamous Cell Carcinoma in A Domestic Cat

Viruses, Vol. 12, Pages 124: Identification of A Novel Papillomavirus Associated with Squamous Cell Carcinoma in A Domestic Cat Viruses doi: 10.3390/v12010124 Authors: Carrai Van Brussel Shi Li Chang Munday Voss McLuckie Taylor Laws Holmes Barrs Beatty Papillomaviruses infect the skin and mucosal surfaces of diverse animal hosts with consequences ranging from asymptomatic colonization to highly malignant epithelial cancers. Increasing evidence suggests a role for papillomaviruses in the most common cutaneous malignancy of domestic cats, squamous cell carcinoma (SCC). Using total DNA sequencing we identified a novel feline papillomavirus in a nasal biopsy taken from a cat presenting with both nasal cavity lymphoma and recurrent squamous cell carcinoma affecting the nasal planum. We designate this novel virus as Felis catus papillomavirus 6 (FcaPV6). The complete FcaPV6 7453 bp genome was similar to those of other feline papillomaviruses and phylogenetic analysis revealed that it was most closely related to FcaPV3, although was distinct enough to represent a new viral type. Classification of FcaPV6 in a new genus alongside FcaPVs 3, 4 and 5 is supported. Archived excisional biopsy of the SCC, taken 20 months prior to presentation, was intensely positive on p16 immunostaining. FcaPV6, amplified using virus-specific, but not consensus, PCR, was the only papillomavirus detected in DNA extracted from the SCC. Conversely, renal lymphoma,...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research