Evaluation of daily walking activity and gait profiles: a novel application of a time series analysis framework - Buckley C, McArdle R, Galna B, Thomas A, Rochester L, Del Din S.

Wearable technology allows an in-depth analysis of gait behaviour in free-living environments. This investigation aimed to use Alzheimer's disease as an example to apply the time series analysis technique of Statistical Parametric Mapping (SPM) to create d...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

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AbstractThe classic neuropathological features of Alzheimer's disease (AD) are accompanied by other complications, including alterations in adult cell proliferation and neurogenesis. Moreover, recent studies have shown that traditional markers of the neurogenic process, such as doublecortin (DCX), may also be expressed in CD8+ T cells and ionized calcium binding adaptor molecule 1 (Iba1+) microglia, in the close proximity to senile plaques, increasing the complexity of the condition. Altered glucose tolerance, observed in metabolic alteratioins, may accelerate the neurodegenerative process and interfere with normal adult c...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionThese findings provide further support that race modifies the AD phenotypes downstream from cerebral amyloid deposition, and identifies key inter-subsystem connections for deep imaging and neuropathologic characterization.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
When PET scans reveal elevated amyloid levels in cognitively normal older adults,...Read more on AuntMinnie.comRelated Reading: FDG-PET shows where exercise could stall Alzheimer's PET, MRI link amyloid plaque with swift decline Who should get brain scans for Alzheimer's disease? PET, MRI show physical activity aids brain health Would high amyloid level spur physician-assisted death?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Title: AHA News: Diabetes, Alzheimer's Together Might Increase Stroke SeverityCategory: Health NewsCreated: 2/17/2020 12:00:00 AMLast Editorial Review: 2/18/2020 12:00:00 AM
Source: MedicineNet Heart General - Category: Cardiology Source Type: news
(Alzheimer Europe) Today, at a European Parliament lunch debate, Alzheimer Europe launched a new report presenting the findings of its collaborative analysis of recent prevalence studies and setting out updated prevalence rates for dementia in Europe. The report findings show that, despite a marked reduction in the prevalence of dementia, the number of people with dementia is nonetheless set to double by 2050.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
For a variety of sporadic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, it is well-established that ethnicity do affect the disease phenotypes. However, how the ethnicity could contribute to the clinical symptoms and disease progressions in monogenetic disorders, such as spinocerebellar ataxia type 3 (SCA3), remains less studied.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Photo credit Niklas Hamann  “My mom is 81 and lives alone in her condo,” Judy Hanson writes. “Her arthritis is painful, but she gets around with a walker. Her mind is okay for now, though she is sometimes forgetful. I also feel that she is lonely. “I’m worried about her safety and have been telling her for several years that she needs help,” she continues. “I’m not proud to say that I’ve stooped to yelling at her, but I have done it. I hate the thought of her falling and not having help, and I also think she’d be happier with more company. There’s ...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
AbstractPurpose of ReviewWest Nile virus (WNV) emerged from Central Africa in the 1990s and is now endemic throughout much of the world. Twenty years after its introduction in the USA, it is becoming apparent that neurological impairments can persist for years following infection. Here, we review the epidemiological data in support of such long-term deficits and discuss possible mechanisms that drive these persistent manifestations.Recent FindingsFocusing on the recently discovered antimicrobial roles of amyloid and alpha-synuclein, we connect WNV late pathology to overlapping features encountered in neurodegenerative dise...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
AbstractTo evaluate whether the polygenic profile modifies the development of sporadic Alzheimer ’s disease (sAD) and pathological biomarkers in cerebrospinal fluid (CSF), 462 sAD patients and 463 age-matched cognitively normal (CN) controls were genotyped for 35 single-nucleotide polymorphisms (SNPs) that are significantly associated with sAD. Then, the alleles found to be associated with sA D were used to build polygenic risk score (PRS) models to represent the genetic risk. Receiver operating characteristic (ROC) analyses and the Cox proportional hazards model were used to evaluate the predictive value of PRS for ...
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
Condition:   Alzheimer's Disease Intervention:   Device: MemorEM Sponsors:   NeuroEM Therapeutics, Inc.;   Axiom Clinical Research of Florida;   MegaNano Biotech;   Invicro, Boston;   Left Coast Engineering Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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