Racial disparities in dementia prescribing
Study finds unequal dementia care Related items fromOnMedica Fund specialist dementia training to improve care and save money NHS care lets down 'far too many patients' Experts urge radical action on mental health crises CQC's State of Care report finds standards improving but warns of pressures Statins of small and uncertain benefit in primary prevention
Normal resting heart rate can vary from person to person by up to 70 beats per minute Related items fromOnMedica Good midlife heart health linked to lower dementia risk later on Patients question GPs ’ motives for prescribing statins Papworth Hospital cleared to resume heart ops Marathon running can boost vascular age Migraine may be linked to heightened cardiovascular disease risk
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No more effective than placebo; and their help with sleep problems might be short-lived as tolerance develops Related items fromOnMedica Statins of small and uncertain benefit in primary prevention Pharmacists could offer high-dose statins direct to patients UK research reveals racial inequalities in diabetes care Fund specialist dementia training to improve care and save money New evidence on benzodiazepine link to Alzheimer ’s
There are inconsistent results on the association between statin use and the risk of dementia. Power et al. conducted a systematic review and concluded that randomized controlled trials (RCTs) and well-conducted observational studies did not support a ...
ConclusionStatins used in AD patients had beneficial effects on the scores of MMSE scale in the short term ( ≤ 12 months), and statins could slow the deterioration of neuropsychiatric status and significantly improve activities of daily living ability in AD patients, but statins did not show an advantage in the change of the ADAS-Cog scale scores.
There are inconsistent results on the association between statin use and the risk of dementia. Power et al. conducted a systematic review and concluded that randomized controlled trials (RCTs) and well-conducted observational studies did not support a causal preventative effect of late-life statin use on cognitive decline or dementia . As concussion is a risk factor of dementia, Redelmeier et al. recently conducted a prospective study to evaluate the association between statin use and the risk of dementia after a concussion in older adults .
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons. Epige...
CONCLUSIONS: This study did not support an association between statin use and diagnostic conversion but suggested a possible association between statin use and cognitive change in EMCI. Additional randomized clinical trials of statins may be warranted in the prodromal EMCI stage of AD. PMID: 31806426 [PubMed - as supplied by publisher]
STATINS are given to people with high low-density lipoprotein and can help prevent narrowing arteries and cardiovascular disease. Do statins increase people ’s risk of dementia?
NIH-funded clinical trial will test statins in 20,000 older adults.