Pragmatic Language Dysfunction in SLE

A recent study is the first to examine pragmatic language skills in patients with systemic lupus erythematosus (SLE), finding that approximately half of SLE patients have pragmatic language dysfunction...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions SLE (Lupus) language dysfunction pragmatic language systemic lupus erythematosus (SLE) Source Type: research

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AbstractThis guideline aims to describe the complement system and the functions of the constituent pathways, with  particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the innate immune system, with multiple membrane-bound and soluble components. There are three distinct enzymatic cascade pathways within the complement system, the classical, alternative and lectin pathways, which converge with the cleavage of central C3. Complement deficiencies account for ~5% of PIDs. The clinical consequences of inherited defects in the complement system...
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: We proposed that the crescents were not uncommon and had important clinical significance in lupus nephritis. The cutoff point of crescents as prognosticator might be nearly 7.39%. PMID: 32054387 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Little is known about the precise aetiology of systemic lupus erythematosus, but treatment should be individualised according to predominant symptoms, organ involvement, response to previous therapy and disease activity and severity.
Source: Trends in Urology and Men's Health - Category: Urology & Nephrology Authors: Tags: Rheumatology Source Type: research
Authors: Shima N, Nakamura J, Saito K, Kamata Y, Nagatani K, Nagashima T, Iwamoto M, Akine D, Saito T, Sato K, Minota S Abstract A 72-year-old woman was admitted to our hospital with bilateral pleural effusions. She had a 31-year history of systemic lupus erythematosus and had been treated with prednisolone and azathioprine. Pleural fluid culture revealed Salmonella enterica subsp. arizonae infection. This pathogen rarely infects humans but is commonly found in the gut flora of reptiles, especially snakes. Our patient had not come in contact with reptiles. Despite antibiotic therapies and negative pleural cultures,...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Butyrylation plays a crucial role in the cellular processes. Due to limit of techniques, it is a challenging task to identify histone butyrylation sites on a large scale. To fill the gap, we propose an approach based on information entropy and machine learning for computationally identifying histone butyrylation sites. The proposed method achieves 0.92 of area under the receiver operating characteristic (ROC) curve over the training set by 3-fold cross validation and 0.80 over the testing set by independent test. Feature analysis implies that amino acid residues in the down/upstream of butyrylation sites would exhibit spec...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
e;zquiz Aguirre S, Sánchez Landa E Abstract INTRODUCTION: whether hypovitaminosis D is an overarching cause of increased mortality or a prognostic marker of poor health has not been well elucidated. OBJECTIVES: we sought to determine the association of serum 25-hydroxyvitamin D [25-(OH)-D3] levels with the clinical biochemical parameters and mortality risk in chronic diseases. METHODS: we reviewed the clinical charts and collected the clinical biochemical parameters of patients diagnosed with chronic conditions who had at least one 25-(OH)-D3 determination, with or without calcium and vitamin D su...
Source: Nutricion Hospitalaria - Category: Nutrition Authors: Tags: Nutr Hosp Source Type: research
Publication date: Available online 13 February 2020Source: Autoimmunity ReviewsAuthor(s): Irene Cecchi, Carlos Perez-Sanchez, Savino Sciascia, Massimo Radin, Ivan Arias de la Rosa, Nuria Barbarroja Puerto, Luca Scudeler, Laura Perez-Sanchez, Alejandra Maria Patiño Trives, Maria Angeles Aguirre Zamorano, Elisa Menegatti, Dario Roccatello, Chary Lopez-Pedrera
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
A recent study published in Lupus Science &Medicine lays out five of the top barriers impeding progress in lupus diagnosis and treatment.1 The Addressing Lupus Pillars for Health Advancement project (ALPHA), led by the Lupus Foundation of America (LFA), researchers at the Tufts School of Medicine Center for the Study of Drug Development (Tufts... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Research Reviews SLE (Lupus) Access to care adherence Biomarkers clinical trials heterogeneity Socioeconomic Impact Source Type: research
Arthritis&Rheumatology, EarlyView.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Letters Source Type: research
Conclusions: Several IMDs have considerable oral involvement. These oral manifestations of the diseases may be overlooked by other specialists leading to a delay in the diagnosis and its management. In order to circumvent this delay, the analysis and evaluation of a disease need to be done by a team comprising of a dental surgeon, dermatologist, and an oral medicine specialist. PMID: 32042465 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
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