LncRNA-ATB Promotes the Tumorigenesis of Ovarian Cancer via Targeting miR-204-3p

Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

Related Links:

Publication date: Available online 17 February 2020Source: Life SciencesAuthor(s): Luiz Antonio Lupi, Maira Smaniotto Cucielo, Henrique Spaulonci Silveira, Letícia Barbosa Gaiotte, Roberta Carvalho Cesário, Fábio Rodrigues Ferreira Seiva, Luiz Gustavo de Almeida ChuffaAbstractToll-like receptors (TLRs) are critical sensors related to inflammation and tumorigenesis. Among all subtypes, the TLR4 is a highly described transmembrane protein involved in the inflammatory process. The TLR4/myeloid differentiation factor 88 (MyD88) signaling pathway has been implicated in oncogenic events in several tissues an...
Source: Life Sciences - Category: Biology Source Type: research
(RMIT University) About 300,000 new cases of ovarian cancer are diagnosed globally each year, with about 60% of women dying within five years after diagnosis. A clinical trial has shown testing for a specific immune biomarker could improve diagnosis.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Conclusion(DW)MRI and PET(CT) showed comparable diagnostic performance for the detection of peritoneal metastases in ovarian and gastrointestinal cancer patients. Since MRI is more widely available than PET(CT) in clinical practice, this potentially is the imaging method of choice in most centers in the future.Key Points• Detection of peritoneal metastases plays an important role in the accurate staging of cancer patients, however, there is no accepted reference standard for the imaging of peritoneal metastases• This meta-analysis shows that (DW)MRI provided the highest sensitivity for the detection of peritoneal...
Source: European Radiology - Category: Radiology Source Type: research
In this study, we found that Lnc-OC1 was significantly higher in PCOS granulosa cells (GCs) compared to non-PCOS GCs. Lnc-OC1 knockdown inhibited cell viability and promoted cell apoptosis, expression of aromatase mRNA and production of estradiol in KGN cells. In PCOS mice, Lnc-OC1 promoted the serum insulin release, production of angiogenesis-related factors and IκBα phosphorylation, which could be partially restored by Lnc-OC1 shRNA. These results suggest that Lnc-OC1 plays an important part in the pathogenesis of PCOS.
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
CONCLUSION: The authors report an unusual case of ruptured jejunal GIST with hemoperitoneum mimicking ovarian carcinoma. Therefore, GIST, in addition to ovarian cancer, should be considered in patients with an increased serum level of CA-125 and an abdominopelvic mass. PMID: 32055272 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
CONCLUSIONS: VTE occurrence in this real-world patient cohort was high, reaching almost 20% in certain groups, like those with disseminated pancreatic, lung or ovarian cancer receiving first-line chemotherapy. Furthermore, VTE occurs mostly as a symptomatic event, being likely a result of the prothrombotic state of malignancy. PMID: 32057213 [PubMed - as supplied by publisher]
Source: International Angiology - Category: Cardiology Tags: Int Angiol Source Type: research
Publication date: Available online 14 February 2020Source: Inorganica Chimica ActaAuthor(s): Aurel Tăbăcaru, Andreea Veronica Botezatu Dediu, Rodica Mihaela Dinică, Geta Cârâc, Vasile Basliu, Maria Paula Cabral Campello, Francisco Silva, Catarina I.G. Pinto, Joana F. Guerreiro, Marta Martins, Filipa Mendes, Fernanda MarquesAbstractA new mixed lanthanide(III) complex [LaNd(μ2-DPY)(μ4-SO4)2(Et3N)]Br2∙2H2O∙MeOH (La-Nd-DPY) was obtained by the reaction of N,N’-diphenacyl-4,4’-dipyridinium dibromide (DPB) with a mixture of La(III) and Nd(III) sulfates in a 2:1 molar ratio, in the presence of...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 15 February 2020Source: The Journal of Molecular DiagnosticsAuthor(s): Ava Kwong, Vivian Yvonne Shin, Jiawei Chen, Isabella Wai-Yin Cheuk, Cecilia YS. Ho, Chun Hang Au, Karen K.L. Chan, Hextan Y.S. Ngan, Tsun Leung Chan, James M. Ford, Edmond SK. MaABSTRACTDifferences in the mutation spectrum across ethnicities suggest that it is important to identify genes in addition to common high penetrant genes to estimate the associated breast cancer risk in Chinese. 1,338 high-risk breast cancer patients who tested negative for germline BRCA1, BRCA2, TP53 and PTEN mutations between 2007-2017 were s...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
AbstractEmerging evidence showed that long noncoding RNA (lncRNA) plays crucial roles in regulating various cancer biological behaviors. Titin ‐antisense RNA1 (TTN‐AS1) has been reported to have crucial roles in cancers but its role in ovarian cancer remains unknown. The levels of TTN‐AS1, microNRA‐15b‐5p (miR‐15b‐5p), and F‐box and WD repeat domain containing 7 (FBXW7) in ovarian cancer cells were measured by quantitative reverse‐transcription PCR. Targets for TTN‐AS1 and miR‐15b‐5p were predicted by bioinformatic tools, and validated by luciferase activity reporter assay. Cell proliferation, colon...
Source: BioFactors - Category: Biochemistry Authors: Tags: Research Communication Source Type: research
AbstractIn the past decades, the roles of carbohydrates in living organisms and their potential use in many fields have been extensively investigated. Sialyl Lewis x (sLex), a member of body carbohydrate, is an inherent blood-type tetrasaccharide on the surface of different cells, the lymphocyte, neutrophil, some T cells, multiple tumor cells and so on. SLex is a common ligand of the three selectins, L-selectin, E-selectin and P-selectin, and plays important roles in multiple physiological phenomenas by interacting with selectins. Under normal physiological conditions, sLex can affect the immune process and fertilization p...
Source: Glycoconjugate Journal - Category: Biochemistry Source Type: research
More News: Cancer | Cancer & Oncology | Ovarian Cancer | Ovaries