The anhedonia is differently modulated by structural covariance network of NAc in bipolar disorder and major depressive disorder

Publication date: Available online 18 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Shaoqiang Han, Qian Cui, Xiao Wang, Yuyan Chen, Di Li, Liang Li, Xiaonan Guo, Yun-Shuang Fan, Jing Guo, Wei Sheng, Feng-Mei Lu, Zongling He, Huafu ChenAbstractDuring depressive episode, bipolar disorder (BD) patients share indistinguishable depression symptoms with major depressive disorder (MDD).However, whether neural correlates underlying the anhedonia, a core feature of depression, is different between BD and MDD remains unknown. To explore neural correlates underlying the anhedonia in BD and MDD, structural T1-weighted images from 36 depressed BD patients, 40 depressed MDD patients matched for depression severity and 34 health controls (HCs) were scanned. Considering the vital role of nucleus accumbens (NAc) in the anhedonia, we constructed the structural covariance network of NAc for each subject. Then, we explored altered structural covariance network of NAc and its interaction with the anhedonia severity in BD and MDD patients. As a result, BD and MDD patients shared decreased structural covariance of NAc connected to prefrontal gyrus, bilateral striatum extending to bilateral anterior insula. Apart from these regions, BD patients presented specifically increased structural covariance of NAc connected to left hippocampus extending to thalamus. The interaction between structural covariance network of NAc and the anhedonia severity in MDD wa...

Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 20, 2020 Category: Psychiatry Source Type: research