Acute and subchronic oral toxicity assessments of Combretum micranthum (Combretaceae) in Wistar rats

ConclusionThe present study revealed that oral administration of CM extract for 28 days, at dosage up to 1000 mg/kg did not induce toxicological damage in rats. From acute toxicity study, the median lethal dose (LD50) of the extract was estimated to be more than 5000 mg/kg.Graphical abstract
Source: Toxicology Reports - Category: Toxicology Source Type: research

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ConclusionsOur study provides fundamental insights on the molecular mechanisms underlying POMC neuron malprogramming in obesogenic contexts.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 16 February 2020Source: Canadian Journal of DiabetesAuthor(s): Tomoyuki Kawada
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
This article aims to classify the severity grading assessments for both insulin resistance (IR) syndrome and status of pancreatic beta (β) islet cells’ function using the homeostasis model assessment method (that is; homeostasis model assessment-insulin resistance [HOMA-IR] and homeostasis model assessment-pancreatic beta (β) islet cells’ function [HOMA-B] indices) with the focus of disseminating this information rapidly for clinical use by physicians in their patients with dysfunctional regulation of glucose metabolism. It will also assist clinicians to prevent and screen for these individuals who ar...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Signaling pathways of red blood cells (RBC) micromechanics regulation, which are responsible for maintaining the microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve an indispensable tool for correction of hemorheological disorders, which accompany a number of systemic diseases (diabetes mellitus I&II, arterial hypertension, malaria, etc.). Namely, activation of certain pathways involving adenylyl cyclase may provide fast adaptive regulation of RBC deformability (RBC-D). However the specific molecular conditions of intracellular signal transduction in mediat...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
A 55-year-old caucasian traveller was admitted to the intensive care unit of Hospital Clinic of Barcelona for severe Plasmodium falciparum malaria after a 4-day business trip to Sierra Leona. His past medical history included hypertension, dyslipidaemia, type 2 diabetes mellitus, obesity and a splenectomy after a car crash, 15 years before the current episode. The patient only took antimalarial chemoprophylaxis with atovaquone/proguanil during the first 4 days of his stay in the malaria endemic region.
Source: Travel Medicine and Infectious Disease - Category: Infectious Diseases Authors: Tags: Diagnostic Challenge Source Type: research
Authors: Adinortey MB, Sarfo JK, Kwarteng J, Adinortey CA, Ekloh W, Kuatsienu LE, Kwadwo Nyarko A Abstract Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey is a herb found mostly in tropical Africa. The plant, commonly found in West Africa, is used in the management of many diseases including cardiovascular, respiratory, haematological, endocrine, and metabolic diseases in Ghana, Nigeria, Benin, Serra Leone, and Senegal. This piece provides comprehensive and updated information on the traditional uses, phytochemical constituents, and pharmacological and toxicological information available on Launaea taraxacifolia ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
In conclusion, in healthy C57Bl/6 mice with normal endothelium, coadministration of haptoglobin but not hemopexin with cell-free hemoglobin prevents acute hemoglobin-induced systemic hypertension by compartmentalizing cell-free hemoglobin in plasma. In murine diseases associated with endothelial dysfunction, haptoglobin therapy appears to be insufficient to prevent hemoglobin-induced vasoconstriction. NEW &NOTEWORTHY Coadministraton of haptoglobin but not hemopexin with cell-free hemoglobin prevents hemoglobin-induced systemic hypertension in mice with a normal endothelium. In contrast, treatment with the same amount o...
Source: AJP: Heart and Circulatory Physiology - Category: Cardiology Authors: Tags: RAPID REPORT Source Type: research
Lantana rhodesiensis Moldenke an herbaceous, belonging to the Verbenaceae family is widely used in Africa folk medicine for the treatment of cancer, measles, malaria, smallpox, strength, coughs, fever, rheumatism, body pains, diabetes mellitus arrhythmia, parasitic diseases, arterial hypertension, old diarrhoeas. Many studies have been conducted on the chemical composition of the whole plant ofL. rhodesiensis as well as biological activities.  The aim of the present review was to give a detailed literature survey on its traditional uses, phytochemistry and therapeutical properties ofL. rhodesiensis.
Source: International Journal of Phytomedicine - Category: Science Authors: Source Type: research
This study analyzes SPEED data from health facilities in the Eastern Visayas region, one of the four regions affected by Typhoon Haiyan, from November 8, 2013 to March 28, 2014.6 The database comprises reports that detail the number of consultations per day by health facility for two age groups (60 days) as this was identified to separate response and recovery.10 As this is a descriptive study of an existing database using aggregated data, the Institutional Review Board of Heidelberg University deemed the study exempt from full review. Prior to the start of the study, the SPEED database for Typhoon Haiyan was requested f...
Source: PLOS Currents Disasters - Category: Global & Universal Authors: Source Type: research
The Human Heredity and Health in Africa Kidney Disease Research Network aims to investigate the genetics of renal disease progression.1 Diabetes mellitus and hypertension have emerged as the commonest cause of end-stage renal disease in Sub-Saharan Africa.2 Additionally, obstructive uropathy (observed in malaria), HIV infection, and toxic nephropathies also contribute considerably. Therefore, apposite management of the above conditions is essential before mapping the phenotype of renal-disease progression to the genotype.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
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