Efficacy of baricitinib on periodontal inflammation in patients with rheumatoid arthritis

Publication date: Available online 18 January 2020Source: Joint Bone SpineAuthor(s): Codrina Ancuţa, Cristina Pomîrleanu, Claudia Mihailov, Rodica Chirieac, Eugen Ancuţa, Cristina Iordache, Codruţa Bran, Oana ȚănculescuAbstractObjective: Despite a widely recognized bidirectional pathobiologic relationship between rheumatoid arthritis (RA) and periodontal disease, the impact of innovative anti-rheumatic drugs in modulating not only inflammatory and immune articular damage, but also periodontal microenvironment remains debatable. We aimed to evaluate the periodontal status in RA with and without baricitinib, a Janus kinase (JAK) inhibitor, and to better describe association between these entities.Methods: We performed a prospective longitudinal 24-weeks study in 21 active RA initiating baricitinib. Standard assessments included a dual rheumatologic (RA activity, disability, serological, inflammatory profile) and dental evaluation comprising plaque index, gingival index, bleeding on probing, probing depth, clinical attachment level.Results: More than half of RA presented at baseline with chronic periodontitis, as suggested by high prevalence of sites with dental plaque, abnormal bleeding on probing, probing depth and clinical attachment level. Aggressive periodontal disease was reported particularly in disease subsets with excessive inflammatory (serum C reactive protein level) and serologic biomarkers (anti-citrullinated peptide antibodies). Furthermore, significant ...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

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Cerebral palsy is the most common cause of childhood motor disability, affecting 2 to 3/1000 children worldwide. Clinical abnormalities in tone, posture, and movement are the result of brain dysgenesis or injury early in life, and impairment varies in type, distribution, and in severity. The underlying brain disorder may also lead to other associated neurologic and systemic impairments. Variability in functional impairments, which can change during development, necessitates an individualized treatment plan. Treatment options are primarily symptomatic and directed toward optimizing independence, function, and/or ease of car...
Source: Neurologic Clinics - Category: Neurology Authors: Source Type: research
Conclusion: We report a 33.9% positive yield, with 65.8% of patients undergoing further workup as a result of CE and 12.7% requiring therapeutic intervention. We conclude that CE plays an important role in the investigation of IDA and occult gastrointestinal bleeding and has important implications on further management.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
Authors: de Seze J, Bigaut K Abstract During the 20 past years, the management of multiple sclerosis (MS) has largely changed especially concerning therapeutical approach. Before 1996, treatments were restricted to corticosteroids for relapses, several symptomatic treatments and unselective immunosuppressive drugs (azathioprine, cyclophosphamide, methotrexate) with a low evidence of any efficacy. In the present review, we analyze the principal real-life cohorts of MS during several periods (before therapeutical modern area, first-generation treatment area and most recent period). Despite many methodological problem...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
CONCLUSIONS: The purpose of the SSI program is to reduce the extent of poverty by providing monthly payments to eligible individuals with disabilities. The authors found that a large and growing number of adults with autism receive SSI benefits. This finding underscores the importance of future research related to the economic security of adults on the autism spectrum. PMID: 32264799 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
Authors: Caplan LJ Abstract This Open Forum describes the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR), a component of the Administration for Community Living under the U.S. Department of Health and Human Services. NIDILRR funds applied research and development projects to improve the abilities of individuals with disabilities, including those with mental illness, to perform activities of their choice in the community and to expand society's capacity to provide full opportunities and accommodations for its citizens with disabilities. PMID: 32264797 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
This study aims to determine the sexual problems of the patients with spinal cord injury and to analyze the relationship between these problems and the hopelessness levels of the patients. This descriptive cross-sectional study, which employed a mixed method (qualitative and quantitative) was conducted on 53 inpatients at a physical therapy and rehabilitation hospital in Turkey. Questionnaire on Sociodemographic and Clinical Characteristics, Arizona Sexual Experiences Scale, Beck Hopelessness Scale and Semi-Structured Interview Form on Sexuality and Hopelessness were used for data collection. Statements of the participants...
Source: Sexuality and Disability - Category: Disability Source Type: research
Publication date: Available online 8 April 2020Source: Journal of Clinical Orthopaedics and TraumaAuthor(s): V. Adukia, J. Mangwani, R. Issac, S. Hussain, L. Parker
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
People with stiff and aching knees due to arthritis get better relief from physical therapy than from cortisone injections, according to a one-year military study comparing the two treatments.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news
At midnight on Thursday March 26, all of South Africa went into lockdown. For the next 21 days, no one is to leave their homes unless they are going to the grocery store, the pharmacy or to seek medical help. No dog walking, no jogging, no food delivery services. Only essential workers are exempt, and that list is small. When President Cyril Ramaphosa made the announcement on March 23, a week after shutting the nation’s schools, there were only 402 confirmed COVID-19 cases. But it was essential, he said, to “flatten the curve” before widespread outbreaks overwhelmed the country’s fragile medical sys...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 feature Londontime Source Type: news
Laura Stronati1, Francesca Palone2, Anna Negroni3, Eleonora Colantoni2, Anna Barbara Mancuso2, Salvatore Cucchiara2, Vincenzo Cesi3, Sara Isoldi2 and Roberta Vitali3* 1Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy 2Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, Rome, Italy 3Division of Health Protection Technologies, Territorial and Production Systems Sustainability Department, ENEA, Rome, Italy Gut mucosal healing (MH) is considered a key therapeutic target and prognostic parameter in the management of inflammatory bowel disease (I...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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