A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
Condition: Crohn's Disease Intervention: Drug: Mirikizumab Sponsor: Eli Lilly and Company Not yet recruiting
In this study, we aimed to describe sexual function in Puerto Rican women with IBD. METHODS: We conducted a cross-sectional study of women with IBD at the University of Puerto Rico Center for IBD. Patients were invited to anonymously complete the validated Spanish version of the Female Sexual Function Index (FSFI) questionnaire. On this 36-point scale, a score of 26.55 or less is defined as sexual dysfunction. Data were analyzed by diagnosis, presence of an ostomy, and age, using descriptive statistics, ANOVA, Student's t test, and logistic regression. RESULTS: One hundred women completed the FSFI questionnaire, wi...
Authors: Kim JY, Lee Y, Choe BH, Kang B Abstract Background/Aims: Anti-drug antibodies (ADAs) can develop during treatment with anti-tumor necrosis factor (TNF) agents. We aimed to investigate the factors associated with immunogenicity of anti-TNF agents in pediatric patients with inflammatory bowel disease (IBD) and observe the clinical course of ADA-positive patients. Methods: Pediatric IBD patients receiving maintenance treatment with anti-TNF agents who had been tested for ADAs against infliximab (IFX) or adalimumab (ADL) were included in this crosssectional study. Factors associated with ADA positivity wer...
CONCLUSION: A 37-year-old man developed infusion-related angioedema with use of infliximab-abda. Discontinuation of the biosimilar product along with supportive care brought about resolution of angioedema. There are no prior published reports of infusion-related angioedema reactions secondary to infliximab-abda use. PMID: 33031494 [PubMed - as supplied by publisher]
Publication date: Available online 7 October 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Pietro Lucotti, Elisabetta Lovati, Marco Vincenzo Lenti, Beatrice Valvo, Elisa Sprio, Nicola Aronico, Paolo Giuffrida, Dominica Dell’Aera, Alessandra Pasini, Cristina Ubezio, Mariangela Delliponti, Carmine Tinelli, Gino Roberto Corazza, Antonio Di Sabatino
Condition: Crohn Disease Interventions: Procedure: high ligation of ileocolic artery; Procedure: mesenteric sparing Sponsor: The Cleveland Clinic Recruiting
CONCLUSIONS: In the present study, the clinical course of CD was similar to previous reports during the first year after diagnosis, but the following years were considerably more stable with moderate increase of intestinal damage and totally a low frequency of surgery and no repeated surgery. PMID: 33016802 [PubMed - as supplied by publisher]
Authors: Duan Y, Liu Y, Li Y Abstract Background: To assess the influence of a previous intestinal resection on postoperative complications for Crohn's disease (CD). Methods: Data on patients with CD undergoing surgery in our department from January 2016 through December 2019 were retrospectively reviewed. Information collected included demographic details, surgical data, and postoperative outcome. A cross-sectional study design was employed. Associations between postoperative complications and preoperative clinical indicators were further analyzed. Results: Of the 129 patients with CD studied, 62 patients ...
Title: Researchers Identify Bacteria Responsible for Key Crohn's ComplicationCategory: Health NewsCreated: 10/6/2020 12:00:00 AMLast Editorial Review: 10/7/2020 12:00:00 AM