Diagnosis of cyanide poisoning using an automated, field-portable sensor for rapid analysis of blood cyanide concentrations.

Diagnosis of cyanide poisoning using an automated, field-portable sensor for rapid analysis of blood cyanide concentrations. Anal Chim Acta. 2020 Feb 15;1098:125-132 Authors: Bortey-Sam N, Jackson R, Gyamfi OA, Bhadra S, Freeman C, Mahon SB, Brenner M, Rockwood GA, Logue BA Abstract Cyanide (both HCN and CN- are represented by CN) has multiple industrial applications, is commonly found in some foods, and is a component of fire smoke. Upon exposure, CN blocks production of adenosine triphosphate, causing cellular hypoxia and cytotoxic anoxia, which can eventually result in death. Considering CN's quick onset of action and the long analysis times associated with current techniques, the objective of this study was to develop and validate a rapid and field-portable sensor to detect blood CN concentrations focusing on both concentration and diagnostic accuracy. The sensor takes advantage of the chemical properties of CN by converting it exclusively to HCN via acidification of whole blood. High-speed headspace transfer is used to deliver HCN to a capture solution where it is reacted with naphthalene dialdehyde and taurine to produce a fluorescent β-isoindole product. Simple spectrofluorometric analysis of the product provides quantitative analysis of CN from whole blood in 60 s and requires only 25 μL of blood (obtainable via fingerstick). A limit of detection of 5 μM, a linear range of 10-200 μM (with ≥15 μM consid...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research

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The authors regret that there were two typographical errors in the Results section of the abstract of the published article. Please see below for the corrected abstract in full. Background: The increasing use of pregabalin and the presence of pre...
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Source: Toxicon - Category: Toxicology Authors: Tags: Toxicon Source Type: research
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PMID: 32220122 [PubMed - as supplied by publisher]
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