Antifungal resistance in patients with Candidaemia: a retrospective cohort study

Candidaemia is the most common form of invasive candidiasis. Resistant Candida blood stream infection (BSI) is rising, with limitations on the development of broader-spectrum antifungal agents worldwide. Our stud...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research

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Publication date: Available online 11 February 2020Source: Journal de Mycologie MédicaleAuthor(s): C.S. Shinobu-Mesquita, E. Martins, J.B. Júnior, P. de Souza Bonfim-Mendonça, M.S.S. Felipe, É.S. Kioshima, T.I.E. Svidzinski
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Publication date: Available online 26 February 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Mehran Varnasiri, Shokrolah Salmanzadeh, Ali Zarei Mahmoudabadi, Marzieh Halvaeezadeh, Simin Taghipour, Shahla Molavi, Seyed Mohammad Alavi, Khojasteh Hoseiny Nezhad, Parastoo Moradi Choghakabodi
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
This study was therefore aimed to assess the in vitro bioactivities associated with the LP EO. The EO was separated by hydrodistillation from the aerial parts of LP plants and analyzed for its antioxidant, antimicrobial, anticholinesterase, and antilipase activities. GC-MS was used for phytochemical analysis. The chemical analysis of the EO composition revealed 25 constituents, of which carvacrol (65.27%) was the most abundant. EO exhibited strong antioxidant (IC50 0.16-0.18 μL/mL), antiacetylcholinesterase (IC50 0.9 μL/mL), antibutyrylcholinesterase (IC50 6.82 μL/mL), and antilipase (IC50 1.0...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Microbial Drug Resistance, Ahead of Print.
Source: Microbial Drug Resistance - Category: Microbiology Authors: Source Type: research
Publication date: Available online 13 February 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Hung-Wei Yang, Un-In Wu, Jung-Hsien Hsieh, Hao-Chih Tai
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Although multidrug-resistant Candida auris infections are rare, New York health officials advise close monitoring of cases after 3 patients in the state were found to have C auris that was resistant to all 3 classes of commonly prescribed antifungal drugs (pan resistance).
Source: JAMA - Category: General Medicine Source Type: research
Candida oleophila is an effective biocontrol agent used to control post-harvest diseases of fruits and vegetables. C. oleophila I-182 was the active agent used in the first-generation yeast-based commercial product, Aspire®, for post-harvest disease management. Several action modes, like competition for nutrients and space, induction of pathogenesis-related genes in host tissues, and production of extracellular lytic enzymes, have been demonstrated for the biological control activity exhibited by C. oleophila through which it inhibits post-harvest pathogens. In the present study, the whole genome of C. oleophila I-182 ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionsOur results indicated that the most active combinations of these species extracts could be useful in the treatment of vaginal infectious diseases caused by Saccharomyces cerevisiae and Candida spp. strains and in associated oxidative and inflammatory processes, supporting its traditional use. In addition, the results highlighted the phyto-therapeutic potential of total phytochemical compounds present in these medicinal plants.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Candida albicans is the most common opportunistic human fungal pathogen. The chemokine ligand CXCL1 plays a protective role in fungal infection through the recruitment of neutrophils. TRAF1 (tumor necrosis factor...
Source: Cell Communication and Signaling - Category: Molecular Biology Authors: Tags: Research Source Type: research
This study was conducted to assess the utility of the T2Candida panel across an academic health center and identify potential areas for diagnostic optimization. A retrospective chart review was conducted on patients with a T2Candida panel and mycolytic/fungal (myco/f lytic) blood culture collected simultaneously during hospitalizations from February 2017 to March 2018. The primary outcome of this study was to determine the sensitivity, specificity, and positive and negative predictive values of the panel compared to myco/f lytic blood culture. Secondary outcomes included Candida species isolated from culture or detected on...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Mycology Source Type: research
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