A comprehension into target binding and spatial fingerprints of noscapinoid analogues as inhibitors of tubulin.

CONCLUSION: The generated spatial fingerprints of noscapinoids would be used for further pharmacophoric amendments of noscapine analogues to design and develop novel potent noscapine based anti-cancer agents.The present molecular modeling study will be helpful to medicinal chemist in understanding the structural features of noscapinoids for further designing and synthesis of target specific safer inhibitors of tubulin that may enter to drug development pipeline. PMID: 31951171 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research