1,2-Diethoxyethane catalyzed oxidative cleavage of gem-disubstituted aromatic alkenes to ketones under minimal solvent conditions

Publication date: Available online 17 January 2020Source: Chinese Chemical LettersAuthor(s): Kai-Jian Liu, Ji-Hui Deng, Tang-Yu Zeng, Xin-Jie Chen, Ying Huang, Zhong Cao, Ying-Wu Lin, Wei-Min HeAbstractAerobic oxidation using pure dioxygen gas as the oxidant has attracted much attention, but its application in synthetic chemistry has been significantly hampered by the complexity of catalytic system and potential risk of high-energy dioxygen gas. By employing 1,2-diethoxyethane as a catalyst and ambient air as an oxidant, an efficient protocol for the construction of various aryl-alkyl and diaryl ketones through oxidative cleavage of gem-disubstituted aromatic alkenes under minimal solvent conditions has been achieved.Graphical abstractBy employing 1,2-diethoxyethane as a catalyst and ambient air as an oxidant, an efficient protocol for the construction of various aryl-alkyl and diaryl ketones through oxidative cleavage of gem-disubstituted aromatic alkenes under minimal solvent conditions has been achieved.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research