Integrated proteomic and metabolomic analysis to study the effects of spaceflight on Candida albicans

In this study, we aim to explore the phenotyp...
Source: BMC Genomics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research

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ConclusionWithin the limitations of this in vitro and in vivo study, the results suggest that the newly developed tissue conditioner containing CPC-Mont has not only excellent antimicrobial properties, but also the same mechanical properties and biocompatibility as tissue conditioners on the market.
Source: Journal of Prosthodontic Research - Category: Dentistry Source Type: research
AbstractBackgroundCandida species are responsible for 15% of bloodstream infections, leading to prolonged hospitalizations and increased mortality. With the rise in obesity, antifungal dosing is unclear. The purpose of this study was to determine differences in clinical outcomes between obese versus non-obese patients withCandida bloodstream infections.MethodsThis retrospective cohort included adult patient ’s first episode ofCandida bloodstream infection treated with  ≥ 48 h of antifungal therapy between 1 June 2013 and 31 August 2019. Patients were excluded for: dual systemic antifungal therap...
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
In this study, 95.3% of the patients were married and 96.7% had only one sexual partner in the mean time. The rate of detection of pathogens were statistically higher in women who have had two or more pregnancies (p
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Authors: Yeşil E, Çelebi S, Sezgin Evim M, Özer A, Turan C, Timur D, Çakır SÇ, Bülbül B, Ener B, Güneş AM, Köksal N, Özkan H, Sevinir B, Düzcan Kilimci D, Hacımustafaoğlu M Abstract Micafungin is recommended especially in patients with liver and kidney failure and in the presence of other side effects due to antifungals apart from its known priority indications such as invasive candidiasis. The aim of this study was to evaluate the children who have received micafungin treatment. In the study, 125 children who were hospitalized in the pediatric wards and ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Publication date: Available online 13 February 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Hung-Wei Yang, Un-In Wu, Jung-Hsien Hsieh, Hao-Chih Tai
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Abstract Candidemia is a significant cause of bloodstream infections (BSI) in nosocomial settings. The identification of species can potentially improve the quality of care and decrease human mortality. Quantitative PCR (qPCR) was evaluated for Candida albicans detection using culture suspensions containing C. albicans , spiked human blood, the cloned qPCR target fragment (ITS2 region) and the results of these assays were compared. The assays showed a good detection limit: C. albicans DNA extracted from yeast (sensitivity 0.2 CFU/µL), spiked human blood (sensitivity 10 CFU/mL), and cloned fragment of ITS2 re...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
To evaluate the optical coherence tomography (OCT) features of retinal lesions in Chinese patients with endogenous Candida endophthalmitis (ECE).
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Research article Source Type: research
Publication date: Available online 12 February 2020Source: Journal of Molecular StructureAuthor(s): Talib H. Mawat, Mohamad J. Al-JebooriAbstractA series of novel metal complexes with bidentate selenosemicarbazone Schiff-base ligands HL1 and HL2 are reported. The reaction of 2-(((3-nitrophenyl)amino)(phenyl) methyl)cyclohexan-1-one and 2-((4-methoxyphenyl)(phenylamino)methyl)cyclohexan-1-one with an ethanolic mixture of KSeCN and NH2NH2 afforded the preparation of the new selenosemicarbazone ligands (E)-2-(2-(((3-nitrophenyl) amino)(phenyl)methyl)cyclohexylidene)hydrazine-1-carboselenoamide (HL1) and (E)-2-(2-((4-methoxyph...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Authors: Supriyadi R, Darmawan G, Pranggono EH Abstract Tuberculosis (TB) remains a worldwide scourge and the most common cause of mortality from infectious disease. Around 95% of cases occur in developing country. Renal TB is a rare cases that complicates 3-4% of pulmonary TB patients and commonly overlooked in clinical practice due to its symptoms may mimic other diseases.A-39-year-old man was admitted to our institution due to flank pain. He had history of low grade fever and oligouria since 5 months prior. He had no complaint of cough, dyspnea, or night sweat. He was a non smoker and had no past medical history...
Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
The objective of the present study was to evaluate whether the small molecule F2768-0318, which was selected by in silico methodologies against NT-Als3 domain, will be able to block the C. albicans adhesion on abiotic and biotic surfaces. F2768-0318 was assessed in tests of biofilm formation and adhesion on abiotic surfaces (polystyrene plates) and adherence on biotic surfaces, including human endocervical (HeLa) cells, human umbilical vein endothelial cells (HUVEC), and fresh buccal epithelial cells (BEC). Our results showed a good performance of F2768-0318 in reducing the adhesion and biofilm formation of C. albicans on ...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
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