AMR Industry Alliance 2020 Progress Report
Source: AMR Industry Alliance. Published: 1/16/2020. The data and case studies collected and published in this 2020 progress report provide insights into the practical steps the Alliance ’s members are taking to curb the spread of antimicrobial resistance in the areas of research and science, access, and appropriate use, as well as steps to reduce the environmental impact of manufacturing. The report outlines a forward-looking agenda listing the next steps which the Alliance is co mmitted to take. (PDF)
ConclusionsIn this study, the majority of MRSE belonged to cluster II domain of CC2. The ST59-IV was a dominant clone among isolates recovered from hospital personnel. Determination of new MLST types confirmed the genetic diversity of these isolates. These observations highlight the need to review the infection control strategies to reduce the carriage of MRSE among hospital personnel.
ConclusionsAn alarming rate of phenotypic resistance was observed in this study. Many isolates were positive for the screened resistance genes. According to the phylogenetic background, most resistant isolates belonged to the commensal phylo-types, representing significant role of commensal strains as a source of resistance genes. These findings highlight the role of pigeon as disseminator of resistant E. coli strains.
Publication date: Available online 22 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Marisa Haenni, Farid El Garch, Christine Miossec, Jean-Yves Madec, Didier Hocquet, Benoit Valot
ConclusionsThe prospective surveillance and active screening for VRE was very useful to determine the true ratio of intestinal colonization to infection and thus helps to shape infection control management.
Publication date: Available online 21 February 2020Source: American Journal of Infection ControlAuthor(s): Aleksa Despotovic, Branko Milosevic, Ivana Milosevic, Nikola Mitrovic, Andja Cirkovic, Snezana Jovanovic, Goran StevanovicBackgroundAcquisition of Hospital-acquired infections (HAIs) in intensive care units (ICUs) predispose patients to higher mortality rates and additional adverse events. Serbian adult ICUs are rarely investigated for HAIs. The aim of this study was to look into HAIs in an adult ICU and identify risk factors for acquisition of HAIs and mortality.MethodsThis retrospective study included 355 patients h...
This article reviews the antimicrobial action of ROS, challenges to ROS hypothesis, researches to encourage ROS–mediated antimicrobial lethality, recent developments in antimicrobial agents using ROS as an antimicrobial strategy, safety concerns related to ROS, and future directions in ROS research.
Authors: Blakiston MR, Freeman JT Abstract AIMS: National responses to antimicrobial resistance (AMR) require an understanding of the factors driving its development and spread. Research to date has primarily focused on determining individual-level risk factors for AMR-associated infections. However, additional insights may be gained by investigating exposures associated with AMR variation at the population level. METHODS: We used an ecological study design to describe the association between the incidence rate of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum β-lactamase producin...
ConclusionTransmission of MSSA is a contributing factor to the occurrence ofS. aureus bacteremia in neonates.Sea andtsst-1 might play a role in neonatalS. aureus bacteremia.
AbstractBackgroundAvailable data on antibiotic resistance in sub-Saharan Africa is limited despite its increasing threat to global public health. As there is no previous study on antibiotic resistance in patients with clinical features of healthcare-associated infections (HAIs) in Sierra Leone, research is needed to inform public health policies. Our study aimed to assess antibiotic resistance rates from isolates in the urine and sputum samples of patients with clinical features of HAIs.MethodologyWe conducted a cross-sectional study of adult inpatients aged ≥18 years at Connaught Hospital, an urban tertiary care...
ConclusionsIn hospital outpatient clinics, a substantial part of therapeutics were inappropriately prescribed. Amoxicillin-clavulanic acid was the most inappropriately prescribed drug, due to non-adherence to the guidelines and because dose adjustment to renal function was often not considered.