Predictive value of traditional risk factors for cardiovascular disease in older people: A systematic review

Publication date: Available online 17 January 2020Source: Preventive MedicineAuthor(s): E.F. van Bussel, M.P. Hoevenaar-Blom, R.K.E. Poortvliet, J. Gussekloo, J.W. van Dalen, W.A. van Gool, E. Richard, E.P. Moll van CharanteAbstractWith increasing age, associations between traditional risk factors (TRFs) and cardiovascular disease (CVD) shift. It is unknown which mid-life risk factors remain relevant predictors for CVD in older people.We systematically searched PubMed and EMBASE on August 16th 2019 for studies assessing predictive ability of>1 of fourteen TRFs for fatal and non-fatal CVD, in the general population aged 60+.We included 12 studies, comprising 11 unique cohorts. TRF were evaluated in 2 to 11 cohorts, and retained in 0–70% of the cohorts: age (70%), diabetes (64%), male sex (57%), systolic blood pressure (SBP) (50%), smoking (36%), high-density lipoprotein cholesterol (HDL) (33%), left ventricular hypertrophy (LVH) (33%), total cholesterol (22%), diastolic blood pressure (20%), antihypertensive medication use (AHM) (20%), body mass index (BMI) (0%), hypertension (0%), low-density lipoprotein cholesterol (0%).In studies with low to moderate risk of bias, systolic blood pressure (SBP) (80%), smoking (80%) and HDL-c (60%) were more often retained. Model performance was moderate with C-statistics ranging from 0.61 to 0.77.Compared to middle-aged adults, in people aged 60+ different risk factors predict CVD and current prediction models perform only moderate ...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research

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Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Review Source Type: research
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Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
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Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
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Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
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Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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