Sumatriptan Does Not Antagonize CGRP-Induced Symptoms in Healthy Volunteers.

CONCLUSION: Sumatriptan does not influence headache score, accompanying symptoms or other symptoms induced by CGRP. Furthermore, a 2-hour CGRP infusion causes a wide range of side effects and does not induce more headache than the usual 20-minute infusion. Thus, the prolonged infusion of CGRP in healthy volunteers is not a valid and pragmatic model for testing new anti-migraine drugs.
PMID: 31944310 [PubMed - as supplied by publisher]

Source: Headache - January 15, 2020 Category: Neurology Authors: Falkenberg K, Rønde Bjerg H, Yamani N, Olesen J Tags: Headache Source Type: research