Antiepileptogenic effect of myricitrin on spatial memory and learning in a kainate-induced model of temporal lobe epilepsy

Publication date: February 2020Source: Learning and Motivation, Volume 69Author(s): Fereshteh Keikhaei, Mohammad Ali Mirshekar, Mohammad Reza Shahraki, Alireza DashipourAbstractTemporal lobe epilepsy (TLE) causes impairment in learning and memory by causing neurological damage. Using the antioxidant and anti-inflammatory effects of myricitrin (MYC), the present study was conducted in order to investigate the neuroprotection effects of MYC in kainic acid (KA) induced- TLE experimental model.Forty male Wistar rats were divided into five groups: 1: Sham, 2: MYC, 3: TLE (epileptic group), 4: VA + TLE (valproic acid and KA recipient), and 5: MYC + TLE (MYC and KA recipient). Intra-hippocampal KA was used for induction of epilepsy. Five mg/kg of MYC was administered from one week before surgery to one hour prior to KA injection intraperitoneally. Shuttle box and Morris water maze tasks were used to investigate passive avoidance and spatial memory respectively. Also, tumor necrosis factor-α (TNF- α) as an inflammatory cytokine, total antioxidant capacity (TAC) and malondialdehyde (MDA) in hippocampal tissue were measured.Intra-hippocampal KA led to the elevation of the severity of seizure scores (SS), hippocampal TNF- α and reduction of TAC concentrations. Administration of MYC attenuated the severity of SS and TNF- α concentrations significantly. The hippocampal TAC concentration increased significantly in the KA + MYC group. Behavioral evaluation also showed that p...
Source: Learning and Motivation - Category: Psychiatry & Psychology Source Type: research