Cardiovascular risk in Psoriatic Arthritis, a narrative review
Conclusion: PsA is characterized by an increase in cardiovascular morbidity in relation with insulin resistance. Current treatments seem to improve this risk with a decrease in cardiovascular mortality in comparison with patients with plaque psoriasis but this requires confirmation in larger prospective studies.
Publication date: Available online 22 February 2020Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyAuthor(s): Jing'an Wang, Dongfang Li, Xin Zhao, Tong Sun, Shengzhen Jin, Hongquan Wang, Tiaoyi Xiao, Yaoguo LiAbstractGrowth hormone (ScGH) and growth hormone receptor (ScGHR) genes from the barbel chub (Squaliobarbus curriculus), in addition to their cDNAs, were cloned. The associations between their mRNA expression levels and growth-related traits were analysed, and the differences in the levels of expression of growth regulation-related genes between the largest and smallest indivi...
Authors: Zeng Y, Chen S, Liu D, Hahn L, Xia X, Wen S, Han Z, Wu X PMID: 32087501 [PubMed - as supplied by publisher]
When it comes to the management of hypertriglyceridemia-associated acute pancreatitis, is IV insulin or conservative treatment the better option?Journal of the Endocrine Society
Well aware of the problems in pharmacy, but can't this be cured by electing Bernie Sanders? I am fine with making less money out of the gate if I have my loans wiped out. And as far as not finding a job, I will certainly be less stressed in between jobs if I have universal healthcare and am not worried about going bankrupt from my insulin.
CONCLUSIONS: The 2019 EULAR/ACR criteria for SLE had comparable performance to the 2012 SLICC criteria regarding diagnostic sensitivity and specificity in Korean population of SLE and other rheumatic diseases. However, the new criteria could not reach higher specificity than the 2012 SLICC criteria. PMID: 32083550 [PubMed - as supplied by publisher]
CONCLUSIONS: Testing for autoantibodies against both Ro peptides may aim diagnosis, classify clinical manifestations in disease entities and define prognosis in certain autoimmune disorders. A distinct weight could be given to the isolated anti-Ro specificities in the SS classification criteria. PMID: 32083547 [PubMed - as supplied by publisher]
CONCLUSIONS: In this cohort the most frequent damage item was renal and was related to the disease itself. Damage score was higher in patients with more severe disease and treated more aggressively. Our results suggest that more effective treatment options are needed in a subgroup of patients with IgA vasculitis to prevent the damage related with the vasculitis, especially with more severe disease. PMID: 32083544 [PubMed - as supplied by publisher]
This study aimed to evaluate the prevalence of metabolic syndrome (MetS) and psoriatic arthritis (PsA) and to investigate HRQoL and the prevalence of hypertension, type 2 diabetes mellitus (T2DM), obesity and dyslipidemia. In a cross‐sectional design, patients d iagnosed with plaque psoriasis answered an interview and standardized questionnaires (Dermatology Life Quality Index questionnaire [DLQI], 36‐Item Short Form Health Survey [SF‐36] and EuroQol Five‐Dimension Questionnaire Three‐Level version [EQ‐5D‐3L]). Physical examination and several t ests to assess desired outcomes were performed by a dermatologis...
CONCLUSION: Psoriatic arthritis appeared significantly associated with subclinical atherosclerosis and endothelial dysfunction and, in turn, with an increased cardiovascular risk. Thus, patients with psoriatic arthritis may benefit from a periodic assessment of surrogate markers of cardiovascular risk. This could help to establish more specific cardiovascular prevention strategies for these patients. PMID: 29542417 [PubMed - as supplied by publisher]
AbstractPurpose of ReviewA growing body of research highlights the use of TNF inhibitors in the treatment of psoriasis and psoriatic arthritis. We aim to review the literature, compile psoriasis efficacy data for TNF inhibitors, and offer advice regarding the approach to treating this condition.Recent FindingsThe results of randomized placebo-controlled studies indicate that TNF inhibitors are efficacious and well tolerated in the treatment of psoriasis. There is a greater prevalence of anxiety, depression, cardiovascular disease, obesity, diabetes, hypertension, dyslipidemia, fatty liver disease, metabolic syndrome, and i...
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