Self-reported Sleep Quality and Bone Outcomes in Older Adults: Findings from the Hertfordshire Cohort Study

In this study, we considered whether perceived sleep quality is also associated with bone health in older adults. We explored this association in a cohort of 443 older community-dwelling UK adults. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI); poor sleep quality was defined as  >  5 on this score system. Bone density, shape and microarchitecture were assessed using dual energy X-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT) and high-resolution pQCT (HRpQCT). Thirty-seven percent of men and 43% of women had a PSQI score greater than 5, indicat ive of poor perceived sleep. We found that quality of sleep was associated with altered bone microarchitecture. In men, poor sleep quality was associated with lower radial trabecular (4% slice,p <  0.04) and cortical (66% slice,p = 0.02) bone mineral density, as well as decreased tibial cortical density (p <  0.02) and increased porosity (p <  0.04), but increased size of the tibia (p <  0.04). In women, poor perceived sleep quality was associated with thinner (p <  0.03) and less dense (p <  0.04) cortices of the radius, but greater tibial trabecular number (p <  0.02) and lower separation (p <  0.04). Relationships with DXA parameters were non-significant after adjustment for confounders. Taking sleep medications was associated with decreased tibial size (38% and 66% slices) and strength in women (allp < ...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research