Phenotypic characterization of macrophages in the BMB sample of human acute leukemia

In this study, 97 BMB samples of patients with acute leukemia and 30 iron-deficiency anemias (IDA) as control group were evaluated with immunohistochemistry. In comparison with controls, the counts of CD68+, CD163+, and CD206+macrophages were remarkably increased in BMB samples of acute leukemia (P <  0.01), as well as their infiltration density was roaring up-regulation (P <  0.01). The expression levels of CD68+, CD163+, and CD206+macrophages were decreased in patients with complete remission, but there still existed statistically significant contrast to the control group (P <  0.01). The ratios of the CD163-positive cells or CD206-positive cells to CD68-positive cells were most prevalent in the BMB samples of human acute leukemia compared with the control group (P <  0.01), which support that macrophages were polarized to M2 macrophages.
Source: Annals of Hematology - Category: Hematology Source Type: research