Clinical efficacy of combination therapy with podophyllotoxin and liquid nitrogen cryotherapy in the treatment of genital warts in men

High prevalence, peculiar etiopathogenesis, and ineffective therapies have contributed to the fact that genital warts are one of the most challenging issues in modern medicine. This prospective study was aimed at determining the clinical efficacy of combination therapy with 0.5% podophyllotoxin solution and liquid nitrogen cryotherapy in the local treatment of genital warts in men. One hundred and ten consecutive male patients with genital warts were randomly assigned to two groups. The control group consisted of two subgroups: 30 patients treated with podophyllotoxin and 30 patients treated with cryotherapy. The experimental group included 50 patients treated with combination therapy. The therapy continued until complete regression, but not longer than six weeks. Analysis of the average increase in the number of cleared warts compared to week zero found a significant clinical improvement in the group treated with a combination therapy in relation to the group treated with podophyllotoxin at the end of each of the six weeks and in comparison with the group treated with cryotherapy at the end of each of the first three weeks. After discontinuation of therapy, a significantly lower recurrence rate and appearance of new condylomas was observed at the end of the third month in the group treated with a combination therapy compared with each group treated with monotherapy, and at the end of the sixth month compared with patients treated with cryotherapy. The combination of podophyl...
Source: Acta Dermatovenerologica Croatica - Category: Dermatology Source Type: research

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Conclusions: 'Cryo-immuno-therapy' is a new combination therapy for multiple common warts. This combination is easy to apply, safe, of low cost, and higher efficacy in contrast to the traditional intralesional Candida antigen monotherapy. PMID: 32009473 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Abstract Warts are benign neoplasms of the skin and mucosa caused by human papillomavirus (HPV) infection.1 The most common treatments for wart are topical application of salicylic acid and cryotherapy. Other modalities include chemical agents, contact sensitizing agents and surgical excision.2 Laser modalities, including carbon dioxide (CO2 ), pulsed dye and neodymium-doped: yttrium-aluminum-garnet lasers, have also been used to treat recalcitrant plantar warts. PMID: 31545511 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
This study mainly concentrates on common and plantar warts. There are various treatment methods for this disease, including the popular immunotherapy and cryotherapy methods. Manual evaluation of the WD treatment response is challenging. Furthermore, traditional machine learning methods are not robust enough in WD classification as they cannot deal effectively with small number of attributes. This study proposes a new evolutionary-based computer-aided diagnosis (CAD) system using machine learning to classify the WD treatment response. The main architecture of our CAD system is based on the combination of improved adaptive ...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
Abstract Condyloma acuminatum (CA) is a benign tumor primarily caused by infection with human papillomavirus (HPV) type-6 or type-11, lesions of which are most frequently found on the genital, perianal squamous mucosa, and skin. CA outside the anogenital region is not common. Here, we report a case showing simultaneous presence of CA on the vaginal orifice, areola, groin, and umbilicus in a 32-year-old pregnant woman. Histopathological examination and HPV detection are essential in making a definitive diagnosis of CA on multiple sites. The patient was treated with microwave and liquid nitrogen cryotherapy, but rep...
Source: Indian Journal of Pathology and Microbiology - Category: Pathology Authors: Tags: Indian J Pathol Microbiol Source Type: research
[Epidemioclinical and Therapeutic Study of Condylomas (Genital Warts) in Dermato-Venereology Department (CHU Treichville, Abidjan, Côte d'Ivoire, 2013-2016)]. Bull Soc Pathol Exot. 2018;111(1):1-4 Authors: Hamdan SK, Yao IK, Diabaté A, Elidje JE, Kaloga M, Kouadio CA, Ildevert PG, Kouamé AK, Sylvain SA, Kassi K, Kanga K, Sangare A Abstract We have conducted a retrospective study in the dermatology department of the CHU Treichville in Abidjan during 4 years. Three hundred and fifty cases of venereal warts were recorded with a hospital frequency of 1.5%, an average age of 29.37, a fem...
Source: Bulletin de la Societe de Pathologie Exotique - Category: Tropical Medicine Tags: Bull Soc Pathol Exot Source Type: research
We report the two cases of genital warts, who had an excellent response with intralesional MMR vaccine.
Source: Indian Journal of Sexually Transmitted Diseases - Category: Infectious Diseases Authors: Source Type: research
Discussion Veruccae plantaris or plantar warts are caused by Human Papillomavirus which causes benign epidermal tumors that often have a cauliflower pattern on the foot that may be elevated or flush with the surrounding skin. Lesions may resemble calluses but the normal footprint pattern is disrupted. The lesions often have pinpoint hemorrhages that appear as black dots. In an immunocompetent individual, the lesions usually have spontaneous resolution within 2 years but the infection may spread to create additional lesions. The lesions may also cause pain or discomfort because of their size or location. There are numerous...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Background: Verrucae are benign epithelial proliferations, caused by human papilloma virus (HPV) infection occurring on the skin and mucosa. Traditional therapeutic options for warts, such as cryotherapy, topical salicylic acid, trichloroacetic acid (TCA) or podophyllin applications, induce a local destruction of the epidermis with proven efficacy but often high recurrence rates or scarring. Nitric-zinc complex is a solution for topical application, inducing a local destruction by tissue denaturation (fixation) rather than erosion (acid hydrolysis).
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: External genital warts (EGW) are the most common viral sexually transmitted infection. Ablative treatments like cryotherapy, curettage and CO2 laser therapy offer rapid onset of effect, fast clearance, and reduction of virus load. However, these procedures are associated with high recurrence rates (RR) of 20%-77% in the short and medium term and do not provide sustained clearance. After laser therapy removal of EGW a RR up to 60% has been reported. Topical sinecatechins 10% is a patient-applied regimen for the treatment of EGW with a low RR (6.5%) at 3 months after completion of the therapy in the pivotal trials conducted so far.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
ConclusionsThe present study revealed 10% garlic extract after 2 months duration therapy on the male genital warts had the similar effect in compare to cryotherapy.
Source: Dermatologica Sinica - Category: Dermatology Source Type: research
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