Cardiotoxicity in Hematopoietic Stem Cell Transplant: Keeping the Beat
This study adds to the body of evidence in describing incidence and type of cardiac events experienced by an allogeneic and autologous HSCT population at one institution from 2012-2017. Sixty-five patients (9.8%) experienced cardiac events, including atrial arrhythmia (N = 39), acute heart failure (N = 9), acute coronary syndrome (N = 7), new onset hypertension (N = 9), with a few instances of bradycardia, ventricular arrhythmia, pericardial effusion, and pericarditis. Our multivariable regression analysis identified age (older), creatinine (higher) and history of coronary artery disease to significantly correlate with risk of cardiac event (p = 0.005, p = 0.039, p = 0.038 respectively). A subgroup analysis of those patients experiencing a cardiac event found pre-transplant atrial dilation by trans-thoracic echocardiogram (TTE) to correlate with increased risk of atrial arrhythmia (33.8% vs. 9.7%, p = 0.03). Patients developing a CE had an increased risk of death within one year (11% vs. 32%, p
Conclusions3D printed stem cells seem to have extensive applications in regenerative medicine for the treatment of various diseases. These cells help seed decellularisation of complete organs for regenerative medicine. This technology also applies to the reconstruction of heart valves and has excellent potential in valvular disease. These cells have higher capabilities to fulfil different medical requirements, but it is challenging to steer its growth as per the need of human kind. Scientists created 3D printed stem cells structure which can grow, and they have performed tissue regeneration experiments on them. Traditional...
AbstractAim of testosterone replacement therapy (TRT) is to improve symptoms and signs of testosterone deficiency including decreased libido, erectile dysfunction, depressed mood, anaemia, loss of muscle and bone mass, by increasing serum testosterone levels to physiologic range. TRT has been used in the last 70 years and overtime, numerous preparations and formulations have been developed to improve pharmacokinetics (PKs) and patient compliance. The routes of delivery approved for use in western world include buccal, nasal, sub dermal, transdermal, and intramuscular (IM). The aim of this narrative review is to describe an...
Condition: Pulmonary Arterial Hypertension Interventions: Drug: Macitentan; Drug: Placebo Sponsor: Actelion Not yet recruiting
Conditions: Pre-Eclampsia; Gestational Hypertension Intervention: Device: OMRON Evolv® blood pressure monitor (Blue-tooth® enabled)&Proprietary Smartphone POP-HT app ® Sponsors: University of Oxford; British Heart Foundation Not yet recruiting
Conditions: 2019 Novel Coronavirus Pneumonia; COVID-19 Interventions: Biological: UC-MSCs; Drug: Placebo Sponsors: Wuhan Union Hospital, China; Wuhan Hamilton Bio-technology Co., Ltd, China. Not yet recruiting
Condition: Multiple Myeloma Intervention: Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University of Copenhagen Recruiting
Condition: Acute Rejection of Cardiac Transplant Intervention: Diagnostic Test: INNOGRAFT Heart Suite Sponsors: Myway Gentics Srl; Policlinico San Matteo Pavia Fondazione IRCCS; Istituto Di Ricerche Farmacologiche Mario Negri Enrolling by invitation
Conditions: Coagulopathy; Liver Transplantation Intervention: Diagnostic Test: Hemosonics Quantra coagulation monitor Sponsors: Cambridge University Hospitals NHS Foundation Trust; HemoSonics LLC Not yet recruiting
ConclusionsLiterature suggests lactate is a useful predictive marker for outcomes post liver surgery especially when measured in the early postoperative phase. Further research is required to standardise the use of lactate measurements in a meaningful therapeutic manner.
Publication date: Available online 17 February 2020Source: Journal of Geriatric OncologyAuthor(s): Elizabeth Levin, Yi Peng, Yuanyuan Ji, David Gilbertson, Vicki A. Morrison