Urinary Phosphate Excretion and Fibroblast Growth Factor 23 in Chronic Kidney Disease

We read with great interest the paper of Houston and colleagues entitled “Associations of Dietary Phosphorus Intake, Urinary Phosphate Excretion, and Fibroblast Growth Factor 23 With Vascular Stiffness in Chronic Kidney Disease”. In a cross-sectional study, the authors studied 74 adult chronic kidney disease (CKD) patients (mean age 64 years, mean creatinine clearance 51 ± 19 mL/min, 64% males, 12% black, 29% diabetic, and 30% received calcium supplements) and declared that fibroblast growth factor 23 (FGF-23) was associated with serum phosphate (r = 0.24, P < .03) and creatinine clearance (r = 20.4, P < .001) but not with dietary phosphorus or 24-hour urinary phosphate excretion (P > .05 for both).
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research