ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma.
CONCLUSIONS: The lack of effect from PT2385 treatment in combination with high cytoplasmic HIF-2α expression at normoxia suggest that HIF-2α have additional roles than acting as an ARNT dependent transcription factor. It is important to further unravel the conditions at which HIF-2α has transcriptional and non-transcriptional roles in neuroblastoma.
PMID: 31945318 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - Category: Cytology Authors: Persson CU, von Stedingk K, Fredlund E, Bexell D, Påhlman S, Wigerup C, Mohlin S Tags: Exp Cell Res Source Type: research
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