The Role of 22q11.2 Deletion Syndrome in the Relationship between Congenital Heart Disease and Scoliosis

For over four decades, clinicians and researchers have suggested a relationship between congenital heart disease (CHD) and scoliosis, attributed to either the disease itself or to the long-term effects of cardiac surgery on the immature thoracic cage. However, no study has yet accounted for 22q11.2 deletion syndrome (22q11.2DS), the second most common cause of CHD after Down syndrome. 22q11.2DS has a scoliosis risk of 50%, but within 22q11.2DS a previous report found no significant association between scoliosis and CHD.

Source: The Spine Journal - January 16, 2020 Category: Orthopaedics Authors: Jelle F. Homans, Steven de Reuver, Tracy Heung, Candice K. Silversides, Erwin N. Oechslin, Michiel L. Houben, Donna M. McDonald-McGinn, Moyo C. Kruyt, Ren é M. Castelein, Anne S. Bassett Tags: Clinical Study Source Type: research