Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase

Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Gui-Yang XIA, Ling-Yan WANG, Jing-Fang ZHANG, Yu-Zhuo WU, Guang-Bo GE, Ya-Nan WANG, Peng-Cheng LIN, Sheng LINAbstractPurpurolides D–F (1–3), three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system, were isolated from the endophytic fungus Penicillium purpurogenum IMM 003. Their structures were unambiguously elucidated based on extensive spectroscopic data analyses, 13C NMR chemical shifts calculations coupled with the DP4+ probability method, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1–3 showed significant inhibitory activity against pancreatic lipase (PL). The result highlights that the presence of 3-hydroxylated decanoic acid moiety at C-14 is important for increasing the inhibition potency against PL.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research