Sarcoidosis diagnosed on granulomas in the explanted heart after transplantation: Results of a French nationwide study

Cardiac sarcoidosis (CS) is a challenging diagnosis. Patients may progress to end-stage congestive heart failure and require cardiac transplantation without ever having been diagnosed. Characteristics and outcomes of patients with granulomas in the explanted hearts are unknown.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research

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AbstractPurposeTo investigate inpatient prevalence, expenditures, and comorbidities of hospitalized patients with sarcoidosis in the USA.MethodsPatients with sarcoidosis were identified within the Nationwide Inpatient Sample (NIS) database for the years 2013 and 2014 using the respective ICD-9 diagnostic code. Data on patient and hospital characteristics, comorbidities, total hospital costs, and total hospitalization charges were collected. A propensity-matched cohort of patients without sarcoidosis from the same database was created and used as comparators for the analysis of comorbidities.ResultsA cohort of 78,055 patien...
Source: Lung - Category: Respiratory Medicine Source Type: research
Publication date: Available online 6 February 2019Source: Journal of Cardiology CasesAuthor(s): Kyoko Odawara, Takahiro Inoue, Yoshitaka HirookaAbstractA 75-year-old woman with no significant medical history was admitted to our hospital with congestive heart failure. Echocardiography revealed left ventricle (LV) systolic dysfunction [LV ejection fraction (LVEF) 18%] and diffuse LV hypokinesis mimicking dilated cardiomyopathy. Her brain natriuretic peptide (BNP) level was elevated (1214.3 pg/mL). Standard medications for heart failure failed to ameliorate her cardiac failure symptoms. Echocardiography on admission re...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Conclusions: The classification performance of DCNN-based features outperformed the CoV-based classification performance. Experimental results suggested that DCNN-based high-dimensional features have a potential of semi-automated diagnosis of CS.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Deep Learning In Molecular Imaging Studies Source Type: research
Abstract Sarcoidosis is a systemic disease characterized by noncaseating granulomas and is often a diagnosis of exclusion. The actual prevalence of cardiac sarcoidosis (CS) is unknown, as studies have demonstrated mixed data. CS may be asymptomatic and is likely more frequently encountered than previously thought. Sudden death may often be the presenting feature of CS. Most deaths attributed to CS are caused by arrhythmias or conduction system disease, and congestive heart failure may occur. Current expert consensus on diagnosis of CS continues to rely on endomyocardial biopsy, in the absence of which, histologic ...
Source: The American Journal of the Medical Sciences - Category: General Medicine Authors: Tags: Am J Med Sci Source Type: research
Case: A-68-year-old female, who was diagnosed as cardiac sarcoidosis (CS) in 2009 June with the occurrence of ventricular tachycardia (VT). Then, ICD implantation was performed, and prednisolone were prescribed (the maintenance dose was 10  mg/day). She underwent catheter ablation for VT in 2013, and after that, she had visited our hospital as an outpatient without any emergency administration. In March 2017, she was transported at emergency department complaining of dyspnea, and she was diagnosed congestive heart failure (CHF) with cardiogenic shock.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
This case report illustrates challenging aspects of diagnosis of isolated cardiac sarcoidosis. Here, we present a 69-year-old female who had been diagnosed as dilated cardiomyopathy before was admitted to our hospital for congestive heart failure. Coronary angiography showed no significant abnormalities. Left ventriculography revealed left ventricular aneurysm. The endomyocardial biopsy specimens showed no significant findings. Cardiac MRI showed late enhancement at the lateral wall of the left ventricle, this finding suggested the presence of cardiac sarcoidosis.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
Abstract AimsCardiac involvement is the main determinant of poor outcomes in sarcoidosis. Right ventricular (RV) dysfunction and left ventricular (LV) late gadolinium enhancement (LGE) have been reported to be predictive of adverse outcome in non‐ischaemic cardiomyopathies. The aim of our study was to determine whether delayed RV LGE with cardiovascular magnetic resonance would be predictive of adverse events in addition to LV LGE during the long‐term follow‐up of pulmonary sarcoidosis patients. Methods and resultsEighty‐four consecutive biopsy‐proven pulmonary sarcoidosis patients were followed for a median of 5...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
510Objectives: Transthyretin cardiac amyloidosis (ATTR) is caused by the extracellular deposition of amyloid fibrils in the heart and results in diastolic dysfunction, conduction abnormalities and congestive heart failure. ATTR can be caused by an inherited mutation TTR gene or by deposition of a wild-type protein associated with ageing. Diagnosis of ATTR and exclusion of light chain amyloidosis (AL) are important for correct patient management. 99mTc-labelled biphosphonates are sensitive and specific for ATTR. We have assessed the feasibility of absolute quantitation of myocardial 99mTechnetium labelled 3,3-diphosphono-1,...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research
In this study, 345 patients with incident sarcoidosis in Olmsted County (Minnesota, USA) during 1976–2013 were identified based on comprehensive medical record review. 345 sex- and age-matched comparators were also identified from the same underlying population. Medical records were individually reviewed for CVD, including coronary artery disease, congestive heart failure, atrial fibrillation, cerebrovascular accident, transient ischaemic attack, peripheral arterial disease and abdominal aortic aneurysm. Cox proportional hazards models with adjustment for age, sex, calendar year and cardiovascular risk factors were u...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research
Authors: Cohen Aubart F, Nunes H, Mathian A, Haroche J, Hié M, Le-Thi Huong Boutin D, Cluzel P, Soussan M, Waintraub X, Fouret P, Valeyre D, Amoura Z Abstract Sarcoidosis is a granulomatous disorder of unknown cause characterized by non-caseating granuloma in young adults. Cardiac involvement is rare and range from 2 to 75% depending on diagnostic criteria. Cardiac involvement in sarcoidosis may be asymptomatic or may manifest as rhythm/conduction troubles or congestive heart failure. The diagnosis and treatment of cardiac sarcoidosis may be challenging. However, advances have come in recent years from the u...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
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