Protective effects of ascorbic acid and calcitriol combination on airway remodelling in ovalbumin-induced chronic asthma.

This study investigated the protective effects of ascorbic acid in combination with calcitriol on airway remodelling in ovalbumin (OVA)-induced chronic asthma.Materials and methods: BALB/c mice were assigned into seven groups: (1) Control; (2) Asthma; (3) Ineffective C (orally 39 mg/kg ascorbic acid); (4) Ineffective D (intraperitoneally 1.5 μg/kg calcitriol); (5) Effective C (orally 130 mg/kg ascorbic acid); (6) Effective D (intraperitoneally 5 μg/kg calcitriol); (7) Combination (orally 39 mg/kg ascorbic acid + intraperitoneally 1.5 μg/kg calcitriol). All animals were sensitized and challenged with OVA except in the control group (normal saline). In all treatment groups, mice were administrated vitamins 30 min before each challenge (three times per week for 8 consecutive weeks).Results: In comparison with the asthma group, co-administration of ineffective doses of ascorbic acid and calcitriol led to the decreased levels of IL-13 (50.5 ± 1.85 vs. 42.13 ± 0.37 pg/mL, p = 0.02) and IgE (58.74 ± 0.43 vs. 45.78 ± 2.05 ng/mL, p = 0.003) as well as the reduction of goblet hyperplasia and subepithelial fibrosis (5 vs. 1 score, p = 0.001 and 5 vs. 2 score, p = 0.001, respectively).Discussion and conclusions: Combination of ascorbic acid with calcitriol in ineffe...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

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Infants in homes with frequent cleaning product use have increased odds for childhood wheeze, asthma
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Pediatrics, Pulmonology, Allergy, Journal, Source Type: news
TUESDAY, Feb. 18, 2020 -- A key to your baby's asthma risk may be as close as your laundry room. Canadian research shows that an infant's exposure to household cleaning products in the first few months of life is tied to heightened odds for asthma...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
BACKGROUND: From a population-based perspective, reports in the peer-reviewed medical literature suggest an increase in the overall prevalence of asthma in recent decades. Applicants for military aviation training with a current or past history of a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
(Canadian Medical Association Journal) Early exposure of babies to household cleaning products is associated with the development of childhood asthma and wheeze by age 3 years, according to new research in CMAJ (Canadian Medical Association Journal).
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
(Simon Fraser University) The study was published today in the Canadian Medical Association Journal. It found that young infants (birth to three months) living in homes where household cleaning products were used frequently were more likely to develop childhood wheeze and asthma by three years of age.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Asthma is a severe and chronic disabling disease affecting more than 300 million people world-wide. While in the past few drugs for treatment of asthma were available, new treatment options are currently emerging which appear to be highly effective in certain subgroups of patients. Accordingly there is a need for biomarkers which allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on micro-arrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed which may discriminate two of the most common forms of asthma, ...
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
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Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
Increasing evidence indicates that the development of asthma is associated with microbial communities in indoor environments.1,2 However, because of high temporal and spatial variations and the multidimensionality of microbiome data set, it is challenging to identify an accurate set of protective and risk microbes for asthma. The current standard is performing association analysis between asthma and microbial community composition or quantity of cellular components (eg, endotoxins or microbial volatile organic compounds).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
In this study, a rapid and precise method based on ultra-high performance liquid chromatography (UPLC) combined with an Orbitrap mass spectrometer (UPLC–Orbitrap–MS/MS) was established in both positive- and negative-ion modes to rapidly identify various chemical components in the tubers of G. conopsea for the first time. Finally, a total of 91 compounds, including 17 succinic acid ester glycosides, 9 stilbenes, 6 phenanthrenes, 19 alkaloids, 11 terpenoids and steroids, 20 phenolic acid derivatives, and 9 others, were identified in the tubers of G. conopsea based on the accurate mass within 3 ppm error. ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Journal of Exposure Science &Environmental Epidemiology, Published online: 18 February 2020; doi:10.1038/s41370-020-0201-yHealth effects of concurrent ambient and tobacco smoke-derived particle exposures at low concentrations in children with asthma
Source: Journal of Exposure Science and Environmental Epidemiology - Category: Epidemiology Authors: Source Type: research
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