Design and optimization of a child-friendly dispersible tablet containing Isoniazid, Pyrazinamide and Rifampicin for treating Tuberculosis in pediatrics.
CONCLUSION: A high-quality child-friendly FDC water-dispersible tablet was developed improving the treatment of TB in pediatric. PMID: 31944867 [PubMed - as supplied by publisher]
Authors: Miller A, Cairns A, Richardson A, Lawrence J Abstract CONTEXT: Tuberculosis (TB) is a serious infectious disease with high rates of morbidity and mortality if left untreated. In Australia, TB has been virtually eradicated in non-Indigenous Australian-born populations but in remote Aboriginal and/or Torres Strait Islander communities TB presents a rare but significant public health issue. Remote health services are most likely to encounter patients with suspected and confirmed TB diagnosis but may be unprepared for supporting someone with this disease and the complexities of balancing public health risk wit...
ConclusionAcute macular neuroretinopathy can complicate intraocular TB. Tuberculosis should be kept as one of the differential diagnosis in patients with AMN. Prognosis is generally good in patients of ocular TB presenting with retinal vascular occlusions.
Publication date: Available online 25 February 2020Source: European Journal of Integrative MedicineAuthor(s): Merlin Young, Jenny Craig
Authors: Gavrila IL, Badea RI, Jude C, Socaciu MA, Comsa M, Badea AF Abstract Abdominal ultrasound (US) performed as a "primary imaging procedure" is an important diagnostic tool in gastroenterol-ogy. Expanding the routine investigation to the lower thoracic region might sometimes accelerate the diagnosis in inconclusive manifestations such as pulmonary pathology.US is a valuable tool in evaluating patients with breathing difficulties, chest pain, hypoxia, or chest trauma. This paper presents the particular situation of a patient hospitalized in the gastroenterology depart-ment, where the US identified si...
Publication date: Available online 26 February 2020Source: Preventive Veterinary MedicineAuthor(s): Giovanna Ciaravino, Josep Espluga, Jordi Casal, Alberto Pacios, Irene Mercader, Alberto Allepuz
Condition: Tuberculosis Interventions: Other: Access to Fast Track TB clinic; Other: Information leaflet for male partner; Other: Home sputum collection; Other: Home HIV testing; Other: Financial incentive Sponsors: Liverpool School of Tropical Medicine; Malawi-Liverpool-Wellcome Trust Clinical Research Programme; London School of Hygiene and Tropical Medicine; University of Liverpool Not yet recruiting
CONCLUSIONS: Our data reveal that a multidisciplinary approach to spine tuberculosis facilitates early and accurate diagnosis and can improve medical and surgical management of this disease. PMID: 32096192 [PubMed - in process]
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTuberculosis (TB) remains a deadly disease. The genetic diversity of Mycobacterium tuberculosis was neglected in the past, but is increasingly recognized as a determinant of immune responses and clinical outcomes of TB. However, how this bacterial diversity orchestrates immune responses to direct differences in TB severity remains unknown. We studied 681 patients with pulmonary TB and found that phylogenetically related M. tuberculosis isolates from cases with mild disease induced robust cytokine responses in macrophages. In contrast, is...
ConclusionsThe character of the periosteal reaction is clearly distinguishable from normal bone but is otherwise non ‐specific, with the exception of distinguishing direct pyogenic bone infection and those not directly related to infection and perhaps allowing identification of renal disease.
Publication date: Available online 24 February 2020Source: Respiratory InvestigationAuthor(s): Sze Shyang Kho, Swee Kim Chan, Mei Ching Yong, Hui Min Cheah, YC Gary Lee, Siew Teck Tie