Genetic Intersections of Language and Neuropsychiatric Conditions

AbstractPurpose of ReviewTo better understand the shared basis of language and mental health, this review examines the behavioral and neurobiological features of aberrant language in five major neuropsychiatric conditions. Special attention is paid to genes implicated in both language and neuropsychiatric disorders, as they reveal biological domains likely to underpin the processes controlling both.Recent FindingsAbnormal language and communication are common manifestations of neuropsychiatric conditions, and children with impaired language are more likely to develop psychiatric disorders than their peers.SummaryMajor themes in the genetics of both language and psychiatry include master transcriptional regulators, likeFOXP2; key developmental regulators, likeAUTS2; and mediators of neurotransmission, likeGRIN2A andCACNA1C.

Source: Current Psychiatry Reports - January 16, 2020 Category: Psychiatry Source Type: research